{"created":"2021-03-01T07:27:57.014306+00:00","id":47894,"links":{},"metadata":{"_buckets":{"deposit":"d665f2f3-2569-420f-8876-fcecad2960c2"},"_deposit":{"id":"47894","owners":[],"pid":{"revision_id":0,"type":"depid","value":"47894"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00047894","sets":["160:523","3:62:5595:6993"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicPageStart":"1701043","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Molecular nutrition & food research"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"礒田, 博子"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1 Scope\nl‐citrulline has recently been reported as a more effective supplement for promoting intracellular nitric oxide (NO) production compared to l‐arginine. Here, the effect of l‐citrulline on skeletal muscle and its influence on exercise performance were investigated. The underlying mechanism of its effect, specifically on the expression of skeletal muscle peroxisome proliferator‐activated receptor‐gamma coactivator‐1α (PGC‐1α), was also elucidated.\n2 Methods and results\nSix‐week‐old ICR mice were orally supplemented with l‐citrulline (250 mg kg−1) daily, and their performance in weight‐loaded swimming exercise every other day for 15 days, was evaluated. In addition, mice muscles were weighed and evaluated for the expression of PGC‐1α and PGC‐1α‐regulated genes. Mice orally supplemented with l‐citrulline had significantly higher gastrocnemius and biceps femoris muscle mass. Although not statistically significant, l‐citrulline prolonged the swimming time to exhaustion. PGC‐1α upregulation was associated with vascular endothelial growth factor α (VEGFα) and insulin‐like growth factor 1 (IGF‐1) upregulation. VEGFα and IGF‐1 are important for angiogenesis and muscle growth, respectively, and are regulated by PGC‐1α. Treatment with NG‐nitro‐l‐arginine methyl ester hydrochloride (l‐NAME), a nitric oxide synthesis inhibitor, suppressed the l‐citrulline‐induced PGC‐1α upregulation in vitro.\n3 Conclusion\nSupplementation with l‐citrulline upregulates skeletal muscle PGC‐1α levels resulting in higher skeletal muscle weight that improves time to exhaustion during exercise.\n","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29797700","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/mnfr.201701043","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1613-4125","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11974242","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Villareal, Myra O."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsukawa, Toshiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isoda, Hiroko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-21"}],"displaytype":"detail","filename":"MNFR_62-14.pdf","filesize":[{"value":"893.4 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"MNFR_62-14","url":"https://tsukuba.repo.nii.ac.jp/record/47894/files/MNFR_62-14.pdf"},"version_id":"e3fd913d-1b5f-4744-9bca-4fee69252573"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"l-Citrulline Supplementation-Increased Skeletal Muscle PGC-1α Expression Is Associated with Exercise Performance and Increased Skeletal Muscle Weight","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"l-Citrulline Supplementation-Increased Skeletal Muscle PGC-1α Expression Is Associated with Exercise Performance and Increased Skeletal Muscle Weight"}]},"item_type_id":"5","owner":"1","path":["523","6993"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-21"},"publish_date":"2018-09-21","publish_status":"0","recid":"47894","relation_version_is_last":true,"title":["l-Citrulline Supplementation-Increased Skeletal Muscle PGC-1α Expression Is Associated with Exercise Performance and Increased Skeletal Muscle Weight"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:19:58.894600+00:00"}