{"created":"2021-03-01T07:27:54.564673+00:00","id":47861,"links":{},"metadata":{"_buckets":{"deposit":"d824f2ab-217d-4e38-9ffa-15836822451d"},"_deposit":{"id":"47861","owners":[],"pid":{"revision_id":0,"type":"depid","value":"47861"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00047861","sets":["160:847"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"2431","bibliographicPageStart":"2421","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"G3"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤村, 京一"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ELYS determines the subcellular localizations of Nucleoporins (Nups) during interphase and mitosis. We made loss-of-function mutations of Elys in Drosophila melanogaster and found that ELYS is dispensable for zygotic viability and male fertility but the maternal supply is necessary for embryonic development. Subsequent to fertilization, mitotic progression of the embryos produced by the mutant females is severely disrupted at the first cleavage division, accompanied by irregular behavior of mitotic centrosomes. The Nup160 introgression from D. simulans shows close resemblance to that of the Elys mutations, suggesting a common role for those proteins in the first cleavage division. Our genetic experiments indicated critical interactions between ELYS and three Nup107–160 subcomplex components; hemizygotes of either Nup37, Nup96 or Nup160 were lethal in the genetic background of the Elys mutation. Not only Nup96 and Nup160 but also Nup37 of D. simulans behave as recessive hybrid incompatibility genes with D. melanogaster. An evolutionary analysis indicated positive natural selection in the ELYS-like domain of ELYS. Here we propose that genetic incompatibility between Elys and Nups may lead to reproductive isolation between D. melanogaster and D. simulans, although direct evidence is necessary.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Genetics Society of America"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29773558","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1534/g3.118.200361","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 Hirai et al."},{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2160-1836","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirai, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Zhuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Takaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Awasaki, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wada, Moe"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Keira, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroyuki O."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawamura, Kyoichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-20"}],"displaytype":"detail","filename":"G3_8-7.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"G3_8-7","url":"https://tsukuba.repo.nii.ac.jp/record/47861/files/G3_8-7.pdf"},"version_id":"71f08847-f240-4869-a5ab-2c4a4f9b907f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes"}]},"item_type_id":"5","owner":"1","path":["847"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-20"},"publish_date":"2018-09-20","publish_status":"0","recid":"47861","relation_version_is_last":true,"title":["Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:17:52.559469+00:00"}