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In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity
http://hdl.handle.net/2241/00152027
http://hdl.handle.net/2241/0015202738818888-f4af-45ca-aafe-015f7cf2afd7
名前 / ファイル | ライセンス | アクション |
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CMMI_3612027 (6.1 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-06-18 | |||||
タイトル | ||||||
タイトル | In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Fukumitsu, Nobuyoshi
× Fukumitsu, Nobuyoshi× Yeh, Skye Hsin-Hsien× Flores II, Leo Garcia× Mukhopadhyay, Uday× Young, Daniel× Ogawa, Kazuma× Jeong, Hwan-Jeong× Tong, William× Gelovani, Juri G. |
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著者別名 |
福光, 延吉
× 福光, 延吉 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity. Purpose. We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([18F]fluoroacetamido)-1-hexanoicanilide ([18F]FAHA) as a positron emission tomography (PET) imaging agent for HDAC IIa. Materials and Methods. [18F]FAHA and [18F]fluoro-2-deoxy-2-D-glucose ([18F]FDG) PET studies were done in 24 mice on 2 consecutive days and again 1 week later. The mice were divided into three groups according to drug administration between the first and second imaging sessions (Group A: cisplatin 2 mg/kg, twice; Group B: cisplatin 4 mg/kg, twice; Group C: cisplatin 4 mg/kg, twice, and SAHA 300 mg/kg pretreatment, 4 times). Results. The value of [18F]FAHA was increased and the percentage of injected dose/tissue g (% ID/g) of [18F]FDG was decreased in the brains of animals in Groups A and B. The value of [18F]FAHA and % ID/g of [18F]FDG were not significantly different in Group C. Conclusions. [18F]FAHA PET clearly showed increased HDAC activity suggestive of cisplatin neurotoxicity in vivo, which was blocked by SAHA pretreatment. | |||||
書誌情報 |
Contrast media & molecular imaging 巻 2018, p. 1-12, 発行日 2018-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1555-4309 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12058342 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29755299 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2018/3612027 | |||||
権利 | ||||||
権利情報 | © 2018 Nobuyoshi Fukumitsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley Hindawi |