{"created":"2021-03-01T07:26:37.206000+00:00","id":46683,"links":{},"metadata":{"_buckets":{"deposit":"5ac55dc7-5f1f-480c-a4be-3ebcf60f0e1e"},"_deposit":{"id":"46683","owners":[],"pid":{"revision_id":0,"type":"depid","value":"46683"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00046683","sets":["2780:1763","2780:1769","2780:2202","2780:913","2780:915","3:62:5296:6747"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"661","bibliographicPageStart":"653","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"Arthritis & rheumatology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"住田, 孝之"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"瀬川,  誠司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 功"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"近藤, 裕也"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"坪井, 洋人"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the joint synovium and infiltration by activated inflammatory cells. CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathologic process. In general, CD4+ T cells differentiate into various T helper cell subsets and acquire the functional properties to respond to specific pathogens, and also mediate some autoimmune disorders such as RA. Because the differentiation of T helper cell subsets is determined by the expression of specific transcription factors in response to the cytokine environment, these transcription factors are considered to have a role in the pathology of RA. Treg cells control an excess of T cell–mediated immune response, and the transcription factor FoxP3 is critical for the differentiation and function of Treg cells. Treg cell dysfunction can result in the development of systemic autoimmunity. In this review, we summarize how the expression of transcription factors modulates T helper cell immune responses and the development of autoimmune diseases, especially in RA. Understanding the role of transcription factors in the pathogenesis of autoimmunity may lead to novel therapeutic strategies to control the differentiation and function of both T helper cells and Treg cells.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"wiley"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29245178","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/art.40398","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23265191","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12667238","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kondo, Yuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokosawa, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, Shunta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuyama, Kotona"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Segawa, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuboi, Hiroto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumida, Takayuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-13"}],"displaytype":"detail","filename":"AR_70-5.pdf","filesize":[{"value":"649.7 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"AR_70-5","url":"https://tsukuba.repo.nii.ac.jp/record/46683/files/AR_70-5.pdf"},"version_id":"dcaaa565-557f-4523-a41c-b050f2879585"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis"}]},"item_type_id":"5","owner":"1","path":["1763","913","2202","1769","915","6747"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-13"},"publish_date":"2018-06-13","publish_status":"0","recid":"46683","relation_version_is_last":true,"title":["Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:18:46.509649+00:00"}