{"_buckets": {"deposit": "35da332c-1af0-40ef-b9c1-2bda806a247f"}, "_deposit": {"id": "46488", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "46488"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00046488"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "290", "bibliographicVolumeNumber": "18", "bibliographic_titles": [{"bibliographic_title": "BMC cancer"}]}]}, "item_5_creator_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u897f\u5c71, \u535a\u4e4b"}], "nameIdentifiers": [{"nameIdentifier": "695", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20324642", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000020324642"}, {"nameIdentifier": "0000003058", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000003058"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background\n\nTo compare the prevalence of nephrotoxicity between patients with a solitary-functioning kidney versus those with bilateral-functioning kidneys during the administration of cisplatin-based chemotherapy for advanced urothelial carcinoma.\n\nMethods\n\nWe retrospectively analyzed 244 advanced urothelial carcinoma patients treated with cisplatin-based chemotherapy between 2004 and 2010 at 17 institutes in Japan. The 24 h creatinine clearance, Cockcroft\u2013Gault formula, and estimated glomerular filtration rate equation (eGFR), were compared before all chemotherapies. The urinary tract function status was determined based on the data of nephroureterectomy, hydronephrosis, and relief of upper urinary tract obstruction. A total of 244 patients were divided into four groups according to their urinary tract functioning status and eGFR results, including bilateral-functioning kidneys with pretreatment eGFR \u226560 mL/min/1.73 m2 group (n\u2009=\u200983, 34.0%); a solitary-functioning kidney with pretreatment eGFR \u226560 mL/min/1.73 m2 group (n\u2009=\u200936, 14.8%); bilateral-functioning kidneys with pretreatment eGFR \u003c\u200960 mL/min/1.73 m2 group (n\u2009=\u200945, 18.4%); and a solitary-functioning kidney with pretreatment eGFR \u003c\u200960 mL/min/1.73 m2 group (n\u2009=\u200980, 32.8%).\n\nResults\n\nThe prevalence of nephrotoxicity with impaired eGFR of \u003e\u200910% and 30% from baseline in the post-third-course of chemotherapy was significantly higher in patients with bilateral-functioning kidneys than in those with a solitary-functioning kidney, among patients with pretreatment eGFR \u003c\u200960 mL/min/1.73 m2 (p\u2009=\u20090.023 and p\u2009=\u20090.026). During all courses of chemotherapy, the prevalence of nephrotoxicity with impaired eGFR of \u003e\u200920% from baseline were significantly higher in patients with bilateral-functioning kidneys than those with a solitary-functioning kidney among patients with pretreatment eGFR \u003c\u200960 mL/min/1.73 m2 (p\u2009=\u20090.034), whereas no significant difference was observed among patients with pretreatment eGFR \u226560 mL/min/1.73 m2.\n\nConclusions\n\nThe results suggest that cisplatin-based chemotherapy may have more nephrotoxicity in patients with bilateral-functioning kidneys than in those with a solitary-functioning kidney.\n", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "BioMed Central "}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "29540229", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1186/s12885-018-4186-z", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1471-2407", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12034763 ", "subitem_source_identifier_type": "NCID"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Inoue, Takamitsu"}], "nameIdentifiers": [{"nameIdentifier": "190276", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Jun"}], "nameIdentifiers": [{"nameIdentifier": "190277", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichioka, Daishi"}], "nameIdentifiers": [{"nameIdentifier": "190278", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Narita, Shintaro"}], "nameIdentifiers": [{"nameIdentifier": "190279", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kageyama, Susumu"}], "nameIdentifiers": [{"nameIdentifier": "190280", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugimoto, Mikio"}], "nameIdentifiers": [{"nameIdentifier": "190281", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitsuzuka, Koji"}], "nameIdentifiers": [{"nameIdentifier": "190282", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shiraishi, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "190283", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kinoshita, Hidefumi"}], "nameIdentifiers": [{"nameIdentifier": "190284", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakeda, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "190285", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nomoto, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "190286", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Eiji"}], "nameIdentifiers": [{"nameIdentifier": "190287", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsui, Yoshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "190288", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujie, Keiko"}], "nameIdentifiers": [{"nameIdentifier": "190289", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Habuchi, Tomonori"}], "nameIdentifiers": [{"nameIdentifier": "190290", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishiyama, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": 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true, "title": ["A comparison of nephrotoxicity between patients with a solitary-functioning kidney and those with bilateral-functioning kidneys in cisplatin-based chemotherapy for advanced urothelial carcinoma: a Japanese retrospective multi-institutional study"], "weko_shared_id": 5}