{"created":"2021-03-01T07:26:24.107732+00:00","id":46483,"links":{},"metadata":{"_buckets":{"deposit":"15bb6dd5-3aea-460f-a735-096b2b2fb35b"},"_deposit":{"id":"46483","owners":[],"pid":{"revision_id":0,"type":"depid","value":"46483"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00046483","sets":["2780:1505","2780:6388","3:62:5593:6646"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"15","bibliographicPageStart":"10","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"The Korean Journal of Pain"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福田, 妙子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"田中, 誠"}],"nameIdentifiers":[{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Background\nTo identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the activities of the primary afferent fibers at the dorsal horn.\n\nMethods\nIn experiment 1, 45 rats were assigned to Control, Allo small-dose (0.16 mg/kg), and Allo large-dose (1.6 mg/kg) groups (n = 15 in each). The weight bearing and mechanical withdrawal thresholds of the hind limb were measured before and at 2, 24, 48, and 168 h after Brennan's surgery. In experiment 2, 16 rats were assigned to Control and Allo (0.16 mg/kg) groups (n = 8 in each). The degree of spontaneous pain was measured using the grimace scale after the surgery. Activities of the primary afferent fibers in the spinal cord (L6) were evaluated using immunohistochemical staining.\n\nResults\nIn experiment 1, the withdrawal threshold of the Allo small-dose group was significantly higher than that of the Control group at 2 h after surgery. Intergroup differences in weight bearing were not significant. In experiment 2, intergroup differences in the grimace scale scores were not significant. Substance P release in the Allo (0.16 mg/kg) group was significantly lower than that in the Control group.\n\nConclusions\nSystemic administration of Allo inhibited mechanical allodynia and activities of the primary afferent fibers at the dorsal horn in a rat postoperative pain model. Allo was proposed as a candidate for postoperative pain management.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Korean Pain Society"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29372021","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3344/kjp.2018.31.1.10","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited."},{"subitem_rights":"Copyright ⓒ The Korean Pain Society, 2018"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2005-9159","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Masahide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Taeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takasusuki, Toshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 誠"},{"creatorName":"タナカ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-23"}],"displaytype":"detail","filename":"KJP_31-1.pdf","filesize":[{"value":"565.3 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"KJP_31-1","url":"https://tsukuba.repo.nii.ac.jp/record/46483/files/KJP_31-1.pdf"},"version_id":"483f7e0c-8c94-479b-b777-29e75a5365f0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model"}]},"item_type_id":"5","owner":"1","path":["1505","6388","6646"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-23"},"publish_date":"2018-05-23","publish_status":"0","recid":"46483","relation_version_is_last":true,"title":["Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:18:21.398844+00:00"}