{"created":"2021-03-01T07:26:23.636414+00:00","id":46474,"links":{},"metadata":{"_buckets":{"deposit":"0eacb667-4094-4b79-bc46-d9976d8a6ddf"},"_deposit":{"id":"46474","owners":[],"pid":{"revision_id":0,"type":"depid","value":"46474"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00046474","sets":["152:2150","3:62:5598:6621"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"189","bibliographicPageStart":"179","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Physiological genomics"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐久間, 淳"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent genome-wide association studies have identified various obesity or metabolic syndrome (MetS) susceptibility loci. However, most studies were conducted in a cross-sectional manner. To address this gap, we performed a longitudinal exome-wide association study to identify susceptibility loci for obesity and MetS in a Japanese population. We traced clinical data of 6,022 Japanese subjects who had annual health check-ups for several years (mean follow-up period, 5 yr) and genotyped ~244,000 genetic variants. The association of single nucleotide polymorphisms (SNPs) with body mass index (BMI) or the prevalence of obesity and MetS was examined in a generalized estimating equation model. Our longitudinal exome-wide association studies detected 21 BMI- and five MetS-associated SNPs (false discovery rate, FDR <0.01). Among these SNPs, 16 have not been previously implicated as determinants of BMI or MetS. Cross-sectional data for obesity- and MetS-related phenotypes in 7,285 Japanese subjects were examined in a replication study. Among the 16 SNPs, three (rs9491140, rs145848316, and rs7863248) were related to BMI in the replication cohort (P < 0.05). In conclusion, three SNPs [rs9491140 of NKAIN2 (FDR = 0.003, P = 1.9 × 10−5), rs145848316 of KMT2C (FDR = 0.007, P = 4.5 × 10−5), and rs7863248 of AGTPBP1 (FDR = 0.006, P = 4.2 × 10−5)] were newly identified as susceptibility loci for BMI.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Physiological Society"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29341862","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1152/physiolgenomics.00117.2017","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 American Physiological Society. All rights reserved."},{"subitem_rights":"Licensed under Creative Commons Attribution CC-BY 4.0"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1094-8341","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11704248","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasukochi, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakuma, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeuchi, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Kimihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oguri, Mitsutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimaki, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horibe, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Yoshiji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-22"}],"displaytype":"detail","filename":"PR_50-3.pdf","filesize":[{"value":"265.8 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"PR_50-3","url":"https://tsukuba.repo.nii.ac.jp/record/46474/files/PR_50-3.pdf"},"version_id":"52c35601-85be-4e61-8b0a-7b1766723402"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population"}]},"item_type_id":"5","owner":"1","path":["2150","6621"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-22"},"publish_date":"2018-05-22","publish_status":"0","recid":"46474","relation_version_is_last":true,"title":["Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:18:22.291326+00:00"}