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Microglial dynamics during brain development
http://hdl.handle.net/2241/00151760
http://hdl.handle.net/2241/00151760cbce896f-5118-4b11-9e18-c5fee7630ee5
名前 / ファイル | ライセンス | アクション |
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NRR_13-2 (225.9 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-05-22 | |||||
タイトル | ||||||
タイトル | Microglial dynamics during brain development | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tsuruta, Fuminori
× Tsuruta, Fuminori× Okajima, Tomomi |
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著者別名 |
鶴田, 文憲
× 鶴田, 文憲 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Microglia are the resident immune cells of the central nervous system (CNS). In the normal state, microglia have a ramified shape and continuously survey the conditions of the brain. In response to various stimuli, some microglia change to an amoeboid shape. This type of microglia is motile and produces several secretory proteins, including inflammatory cytokines and neurotrophic factors, which regulate brain homeostasis. Microglial morphology also changes a great deal in concert with environmental factors during brain development, and related to microglial migration and proliferation, which contribute to the establishment of precise synaptic connectivity and neural circuits. In this review, we focus on the fundamental concepts of microglial fate during brain development, and discuss whether the molecular mechanisms that control microglial morphology are linked to microglial functions. | |||||
書誌情報 |
Neural Regeneration Research 巻 13, 号 2, p. 222, 発行日 2018-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1673-5374 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29557363 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.4103/1673-5374.226386 | |||||
権利 | ||||||
権利情報 | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Shar-eAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under identical terms. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Medknow |