{"created":"2021-03-01T07:26:08.635011+00:00","id":46240,"links":{},"metadata":{"_buckets":{"deposit":"aa7151c6-8292-493f-b14a-cea4e7e56499"},"_deposit":{"id":"46240","owners":[],"pid":{"revision_id":0,"type":"depid","value":"46240"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00046240","sets":["152:2150","3:62:5587:6519"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"e409","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Experimental & molecular medicine"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐久間, 淳"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Genome-wide association studies have identified various genetic variants associated with complex disorders. However, these studies have commonly been conducted in a cross-sectional manner. Therefore, we performed a longitudinal exome-wide association study (EWAS) in a Japanese cohort. We aimed to identify genetic variants that confer susceptibility to hypertension using ~244 000 single-nucleotide variants (SNVs) and physiological data from 6026 Japanese individuals who underwent annual health check-ups for several years. After quality control, the association of hypertension with SNVs was tested using a generalized estimating equation model. Finally, our longitudinal EWAS detected seven hypertension-related SNVs that passed strict criteria. Among these variants, six SNVs were densely located at 12q24.1, and an East Asian-specific motif (haplotype) ‘CAAAA’ comprising five derived alleles was identified. Statistical analyses showed that the prevalence of hypertension in individuals with the East Asian-specific haplotype was significantly lower than that in individuals with the common haplotype ‘TGGGT’. Furthermore, individuals with the East Asian haplotype may be less susceptible to the adverse effects of smoking on hypertension. The longitudinal EWAS for the recessive model showed that a novel SNV, rs11917356 of COL6A5, was significantly associated with systolic blood pressure, and the derived allele at the SNV may have spread throughout East Asia in recent evolutionary time.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer "}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29217820 ","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/emm.2017.209","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2017"},{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Inter- national License. The images or other third party material in this article are included in the article ’ s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.  To  view  a  copy  of  this  license,  visit  http:// creativecommons.org/licenses/by-nc-sa/4.0/"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2092-6413","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12037003","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasukochi, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakuma, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeuchi, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Kimihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oguri, Mitsutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimaki, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horibe, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Yoshiji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-26"}],"displaytype":"detail","filename":"EMM_49.pdf","filesize":[{"value":"374.1 kB"}],"format":"application/pdf","licensetype":"license_10","mimetype":"application/pdf","url":{"label":"EMM_49","url":"https://tsukuba.repo.nii.ac.jp/record/46240/files/EMM_49.pdf"},"version_id":"46388363-15d4-4f6e-bb14-6919a3408125"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population"}]},"item_type_id":"5","owner":"1","path":["2150","6519"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-26"},"publish_date":"2018-04-26","publish_status":"0","recid":"46240","relation_version_is_last":true,"title":["Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:18:03.487070+00:00"}