{"created":"2021-03-01T07:25:51.273169+00:00","id":45979,"links":{},"metadata":{"_buckets":{"deposit":"1c3d9339-d578-4a90-a6df-99c5d4cf41e2"},"_deposit":{"id":"45979","owners":[],"pid":{"revision_id":0,"type":"depid","value":"45979"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00045979","sets":["3:62:5591:606","7131:543","7131:988"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"242","bibliographicPageStart":"235","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"International immunology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田原, 聡子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"渋谷, 彰"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mast cells (MCs) play pivotal roles in allergic reactions and the host defense against microbial infection through the IgE-dependent and IgE-independent signaling pathways. MC lines that can be analyzed both in vitro and in vivo would be useful for the study of MC-dependent immune responses. Here, we investigated the functional characteristics of a mouse embryonic stem cell-derived MC-like cell line, MEDMC-BRC6. The cell line expressed FcεRI and c-Kit and showed degranulation and production of inflammatory cytokines and chemokines, including TNF-α, IL-6 and MCP-1, upon cross-linking FcεRI with IgE. These cytokines and chemokines were also produced by the cell line by stimulation of TLR2 and TLR4. MEDMC-BRC6 survived in the peritoneal cavity and the ear skin for at least 6 months after the transfer into genetically compatible MC-deficient KitW-sh/W-sh mice, in which systemic anaphylaxis was successfully induced. Thus, MEDMC-BRC6 cells represent a potent tool for investigating the functions of MCs in vitro and in vivo.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28431112","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/intimm/dxx022","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Japanese Society for Immunology. 2017."},{"subitem_rights":"This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record International Immunology, Volume 29, Issue 5, 1 May 2017, Pages 235–242 is available online at: https://doi.org/10.1093/intimm/dxx022."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0953-8178","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10730708","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibagaki, Shohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tahara-Hanaoka, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiroyama, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibuya, Akira"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-01"}],"displaytype":"detail","filename":"II_29-5.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"InterImmu_29-5","url":"https://tsukuba.repo.nii.ac.jp/record/45979/files/II_29-5.pdf"},"version_id":"7a96155a-e8aa-414f-82cb-9362597b516f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kit W-sh/W-sh mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kit W-sh/W-sh mice"}]},"item_type_id":"5","owner":"1","path":["543","988","606"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-16"},"publish_date":"2018-04-16","publish_status":"0","recid":"45979","relation_version_is_last":true,"title":["Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kit W-sh/W-sh mice"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:14:53.247224+00:00"}