{"created":"2021-03-01T07:25:07.984676+00:00","id":45336,"links":{},"metadata":{"_buckets":{"deposit":"2cd5f66d-6ba1-4d22-a32e-cd8bedce1167"},"_deposit":{"id":"45336","owners":[],"pid":{"revision_id":0,"type":"depid","value":"45336"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00045336","sets":["2780:1523","2780:2605","2780:335","2780:4839","3:62:5296:182"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2812","bibliographicPageStart":"2799","bibliographicVolumeNumber":"91","bibliographic_titles":[{"bibliographic_title":"Archives of toxicology "}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"増田, 知之"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"石井, 一弘"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"田中, 竜太"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"玉岡, 晃"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Diphenylarsinic acid (DPAA) is an organic arsenic compound used for the synthesis of chemical weapons. We previously found that the residents of Kamisu city in Ibaraki Prefecture, Japan, were exposed to DPAA through contaminated well water in 2003. Although mounting evidence strongly suggests that their neurological symptoms were caused by DPAA, the dynamics of DPAA distribution and metabolism after ingestion by humans remain to be elucidated. To accurately predict the distribution of DPAA in the human body, we administrated DPAA (1.0 mg/kg/day) to cynomolgus monkeys (n = 28) for 28 days. The whole tissues from these monkeys were collected at 5, 29, 170, and 339 days after the last administration. The concentration of DPAA in these tissues was measured by liquid chromatography–mass spectrometry. We found that DPAA accumulated in the central nervous system tissues for a longer period than in other tissues. This finding would extend our knowledge on the distribution dynamics and metabolism of DPAA in primates, including humans. Furthermore, it may be useful for developing a treatment strategy for patients who are exposed to DPAA.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer International Publishing AG."}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28120037","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00204-016-1928-z","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2017. This article is published with open access at Springerlink.com"},{"subitem_rights":"This  article  is  distributed  under  the  terms  of  the   Creative   Commons   Attribution   4.0   International   License   ( http:// creativecommons.org/licenses/by/4.0/ ),   which   permits   unrestricted    use, distribution, and reproduction in any medium, provided you give  appropriate  credit  to  the  original  author(s)  and  the  source,  provide  a   link  to  the  Creative  Commons  license,  and  indicate  if  changes  were   made."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0340-5761","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00548865 ","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Masuda, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seto, Yasuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hosoya, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Ryuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwasaki, Nobuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamaoka, Akira"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"AT_91-2799.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"AT_91-2799","url":"https://tsukuba.repo.nii.ac.jp/record/45336/files/AT_91-2799.pdf"},"version_id":"5e038fee-e3d5-4b2e-9fef-d499680ed9a5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys"}]},"item_type_id":"5","owner":"1","path":["2605","1523","335","4839","182"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-20"},"publish_date":"2018-02-20","publish_status":"0","recid":"45336","relation_version_is_last":true,"title":["Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:16:59.812460+00:00"}