@article{oai:tsukuba.repo.nii.ac.jp:00044602,
 author = {Yang, Kyung-Min and Bae, Eunjin and Ahn, Sung Gwe and Pang, Kyoungwha and Park, Yuna and Park, Jinah and Lee, Jihee and Ooshima, Akira and Park, Bora and Kim, Junil and Jung, Yunshin and 高橋, 智 and TAKAHASHI, Satoru and Jeong, Joon and Park, Seok Hee and Kim, Seong-Jin},
 issue = {10},
 journal = {Cell Reports},
 month = {Dec},
 note = {Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers. Here, we report a unique role for Bcl-2-associated athanogene 2 (BAG2), which is significantly overexpressed in TNBC, in regulating the dual functions of cathepsin B as either a pro- or anti-oncogenic enzyme. Silencing BAG2 suppresses tumorigenesis and lung metastasis and induces apoptosis by increasing the intracellular mature form of cathepsin B, whereas BAG2 expression induces metastasis by blocking the auto-cleavage processing of pro-cathepsin B via interaction with the propeptide region. BAG2 regulates pro-cathepsin B/annexin II complex formation and facilitates the trafficking of pro-cathespin-B-containing TGN38-positive vesicles toward the cell periphery, leading to the secretion of pro-cathepsin B, which induces metastasis. Collectively, our results uncover BAG2 as a regulator of the oncogenic function of pro-cathepsin B and a potential diagnostic and therapeutic target that may reduce the burden of metastatic breast cancer.},
 pages = {2952--2964},
 title = {Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells},
 volume = {21},
 year = {2017},
 yomi = {タカハシ, サトル}
}