{"created":"2021-03-01T07:21:23.289400+00:00","id":41896,"links":{},"metadata":{"_buckets":{"deposit":"66e2a024-e76b-4797-9431-980c3ea6da27"},"_deposit":{"id":"41896","owners":[],"pid":{"revision_id":0,"type":"depid","value":"41896"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00041896","sets":["117:306","3:62:5591:1064"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"17","bibliographicPageStart":"11","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"International journal of biological macromolecules"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白木, 賢太郎"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aggregative protein–polyelectrolyte complex (PPC) has been proposed as a concentrated state of protein with a great potential for biopharmaceutical application. In this review article, we introduce a unique concentration method of protein formulation using PPC for a dozen types of pharmaceutical antibodies, hormones, and enzymes. Aggregative PPC can be obtained only by mixing poly(amino acid)s with proteins under low salt concentration conditions at an ambient temperature. The aggregative PPC is in a stabilized state against shaking, heating, and oxidation. More importantly, the aggregative PPC can be fully redissolved by the addition of physiological saline without denaturation and activity loss for many proteins. In addition, the general toxicity and pharmacokinetic profiles of the aggregative PPC are identical to those of the control antibody formulation. Thus, the protein formulation produced by aggregative PPC would be applicable for biomedical use as a kind of concentrated-state protein.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER "}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27287770","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijbiomac.2016.06.016","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2016 Elsevier B.V. All rights reserved."},{"subitem_rights":"This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ "}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01418130","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00233999 ","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kurinomaru, Takaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraki, Kentaro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-01"}],"displaytype":"detail","filename":"IJBM_100.pdf","filesize":[{"value":"597.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"IJBM_100","url":"https://tsukuba.repo.nii.ac.jp/record/41896/files/IJBM_100.pdf"},"version_id":"4fe4343c-2023-4190-8170-93e5ecbc2bf6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aggregative protein–polyelectrolyte complex for high-concentration formulation of protein drugs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aggregative protein–polyelectrolyte complex for high-concentration formulation of protein drugs"}]},"item_type_id":"5","owner":"1","path":["306","1064"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-20"},"publish_date":"2017-07-20","publish_status":"0","recid":"41896","relation_version_is_last":true,"title":["Aggregative protein–polyelectrolyte complex for high-concentration formulation of protein drugs"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:12:53.512765+00:00"}