{"created":"2021-03-01T07:21:15.081977+00:00","id":41770,"links":{},"metadata":{"_buckets":{"deposit":"b7111463-c51a-4dbd-9358-78e25cd44b95"},"_deposit":{"id":"41770","owners":[],"pid":{"revision_id":0,"type":"depid","value":"41770"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00041770","sets":["2770:1487","2780:1777","2780:334","2780:5536","3:62:5592:5991"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"222","bibliographicPageStart":"214","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"Journal of pharmacological sciences"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中川, 嘉"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"関谷, 元博"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"松坂, 賢"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"島野, 仁"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Peroxisome proliferator-activated receptor α (PPARα) is a well-known therapeutic target for treating hyperlipidemia. K-877 is a novel selective PPARα modulator (SPPARMα) that enhances PPARα transcriptional activity with high selectivity and potency, resulting in reduced plasma lipid levels. This study aimed to evaluate the effects of K-877 on hyperlipidemia in low-density lipoprotein receptor knockout (Ldlr−/−) mice, a mouse model of atherosclerosis. We revealed that K-877 administration significantly decreased plasma triglyceride (TG) and total cholesterol (TC) levels and increased plasma high-density lipoprotein cholesterol (HDL-C) levels in Ldlr−/− mice. K-877 administration to Ldlr−/− mice efficiently increased the gene expression of PPARα and its target genes related to fatty acid oxidation in the liver and small intestine. The same treatment significantly increased ATP-binding cassette a1 gene expression in the liver and small intestine and reduced Niemann Pick C1-like 1 gene expression in the small intestine, suggesting that K-877 administration induced HDL-C production in the liver and small intestine and reduced cholesterol absorption in the small intestine. In conclusion, K-877 administration had pronounced effects on the liver and small intestine in Ldlr−/− mice. K-877 is an attractive PPARα-modulating drug for treating hyperlipidemia that works equally well in both the liver and small intestine.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"},{"subitem_publisher":"Japanese Pharmacological Society"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28366492","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jphs.2017.02.003","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/)."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-8613","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11806667","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takei, Kenta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagawa, Yoshimi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Yunong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Han, Song-iee"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Aoi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekiya, Motohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuzaka, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimano, Hitoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-07-04"}],"displaytype":"detail","filename":"JPS_133-4.pdf","filesize":[{"value":"509.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"JPS_133-4","url":"https://tsukuba.repo.nii.ac.jp/record/41770/files/JPS_133-4.pdf"},"version_id":"09d5d842-e8bd-4af8-b90d-3f82fafe7f09"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice"}]},"item_type_id":"5","owner":"1","path":["1487","334","5536","1777","5991"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-04"},"publish_date":"2017-07-04","publish_status":"0","recid":"41770","relation_version_is_last":true,"title":["Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:12:41.675129+00:00"}