{"created":"2021-03-01T07:21:09.088044+00:00","id":41667,"links":{},"metadata":{"_buckets":{"deposit":"ddc95524-f7d8-49e6-9730-92528cf9b825"},"_deposit":{"id":"41667","owners":[],"pid":{"revision_id":0,"type":"depid","value":"41667"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00041667","sets":["2780:4866","3:62:5595:642"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1417","bibliographicPageStart":"1412","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":" Molecular biology of the cell  "}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武井, 陽介"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In neurons, RNA transport is important for local protein synthesis. mRNAs are transported along dendrites as large RNA granules. The localization and dynamics of Puralpha and Staufen1 (Stau1), major components of RNA transport granules, were investigated in cultured hippocampal neurons. Puralpha-positive granules were localized in both the shafts and spines of dendrites. In contrast, Stau1-positive granules tended to be localized mainly in dendritic shafts. More than 90% of Puralpha-positive granules were positive for Stau1 in immature dendrites, while only half were positive in mature dendrites. Stau1-negative Puralpha granules tended to be stationary with fewer anterograde and retrograde movements than Stau1-positive Puralpha granules. After metabotropic glutamate receptor 5 activation, Stau1-positive granules remained in the dendritic shafts, while Puralpha granules translocated from the shaft to the spine. The translocation of Puralpha granules was dependent on myosin Va, an actin-based molecular motor protein. Collectively our findings suggest the possibility that the loss of Stau1 in Puralpha-positive RNA granules might promote their activity-dependent translocation into dendritic spines, which could underlie the regulation of protein synthesis in synapses. ","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Cell Biology "}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28404748","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1091/mbc.E16-07-0497","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 Mitsumori et al."},{"subitem_rights":"This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1059-1524","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10830484 ","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mitsumori, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takei, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirokawa, Nobutaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-22"}],"displaytype":"detail","filename":"MBC_28-11-1412.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_10","mimetype":"application/pdf","url":{"label":"MBC_28-11-1412","url":"https://tsukuba.repo.nii.ac.jp/record/41667/files/MBC_28-11-1412.pdf"},"version_id":"ef3f712b-38b7-493b-973e-7b645ae6b1d3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Components of RNA granules affect their localization and dynamics in neuronal dendrites","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Components of RNA granules affect their localization and dynamics in neuronal dendrites"}]},"item_type_id":"5","owner":"1","path":["4866","642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-22"},"publish_date":"2017-06-22","publish_status":"0","recid":"41667","relation_version_is_last":true,"title":["Components of RNA granules affect their localization and dynamics in neuronal dendrites"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:12:36.325588+00:00"}