{"created":"2021-03-01T07:20:13.326194+00:00","id":40800,"links":{},"metadata":{"_buckets":{"deposit":"026a2dcb-1137-4c23-983b-7da6ac3ef7b3"},"_deposit":{"id":"40800","owners":[],"pid":{"revision_id":0,"type":"depid","value":"40800"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00040800","sets":["160:1260","160:523","3:62:5297:5267"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"241","bibliographicPageStart":"238","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Biological & pharmaceutical bulletin "}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"礒田, 博子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"繁森, 英幸"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The prevention of amyloid aggregation is promising for the treatment of age-related diseases such as Alzheimer’s (AD) and type 2 diabetes (T2D). Ten antioxidant flavonoids isolated from the medicinal halophyte Tamarix gallica were tested for their amyloid aggregation inhibition potential. Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs. Structure–activity relationship of the flavonoids suggests that the catechol moiety is important for amyloid aggregation inhibition, while the methylation of the carboxyl group in the glucuronide moiety and of the hydroxyl group in the aglycone flavonoids decreased it.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan "}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28154265","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.b16-00801","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 The Pharmaceutical Society of Japan"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158 ","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497 ","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hmidene, Asma Ben "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanaki, Mizuho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Kazuma "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Irie, Kazuhiro "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isoda, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shigemori, Hideyuki "}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-04-04"}],"displaytype":"detail","filename":"BRB_40-2.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BRB_40-2","url":"https://tsukuba.repo.nii.ac.jp/record/40800/files/BRB_40-2.pdf"},"version_id":"82d3cf14-69a1-4595-8712-3d240c6daa84"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases"}]},"item_type_id":"5","owner":"1","path":["523","1260","5267"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-04"},"publish_date":"2017-04-04","publish_status":"0","recid":"40800","relation_version_is_last":true,"title":["Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:11:19.964041+00:00"}