{"created":"2021-03-01T07:20:04.105811+00:00","id":40662,"links":{},"metadata":{"_buckets":{"deposit":"b79b9ae0-5329-4b4e-b59d-bf9b1cca3f90"},"_deposit":{"id":"40662","owners":[],"pid":{"revision_id":0,"type":"depid","value":"40662"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00040662","sets":["3:62:5591:2890"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1925305","bibliographicVolumeNumber":"2017","bibliographic_titles":[{"bibliographic_title":"International journal of endocrinology "}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五所, 正彦"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background. The effect of dipeptidyl peptidase-4 (DPP-4) inhibitors on the regression of carotid IMT remains largely unknown. The present study aimed to clarify whether sitagliptin, DPP-4 inhibitor, could regress carotid intima-media thickness (IMT) in insulin-treated patients with type 2 diabetes mellitus (T2DM). Methods. This is an exploratory analysis of a randomized trial in which we investigated the effect of sitagliptin on the progression of carotid IMT in insulin-treated patients with T2DM. Here, we compared the efficacy of sitagliptin treatment on the number of patients who showed regression of carotid IMT of ≥0.10 mm in a post hoc analysis. Results. The percentages of the number of the patients who showed regression of mean-IMT-CCA (28.9% in the sitagliptin group versus 16.4% in the conventional group, P = 0.022) and left max-IMT-CCA (43.0% in the sitagliptin group versus 26.2% in the conventional group, P = 0.007), but not right max-IMT-CCA, were higher in the sitagliptin treatment group compared with those in the non-DPP-4 inhibitor treatment group. In multiple logistic regression analysis, sitagliptin treatment significantly achieved higher target attainment of mean-IMT-CCA ≥0.10 mm and right and left max-IMT-CCA ≥0.10 mm compared to conventional treatment. Conclusions. Our data suggested that DPP-4 inhibitors were associated with the regression of carotid atherosclerosis in insulin-treated T2DM patients. This study has been registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000007396).","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi Publishing Corporation "}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":" 28250768","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2017/1925305","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 Tomoya Mita et al."},{"subitem_rights":"This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1687-8337","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mita, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katakami, Naoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraiwa, Toshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshii, Hidenori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gosho, Masahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimomura, Iichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watada, Hirotaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-24"}],"displaytype":"detail","filename":"IJE_2017-1925305.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"IJE_2017-1925305","url":"https://tsukuba.repo.nii.ac.jp/record/40662/files/IJE_2017-1925305.pdf"},"version_id":"d24d72fd-6b0d-4dea-8d3e-da59f82d80a9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation"}]},"item_type_id":"5","owner":"1","path":["3074","2890"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-24"},"publish_date":"2017-03-24","publish_status":"0","recid":"40662","relation_version_is_last":true,"title":["The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:08:27.962655+00:00"}