{"created":"2021-03-01T07:20:01.381416+00:00","id":40617,"links":{},"metadata":{"_buckets":{"deposit":"d68b369d-30ba-4ea5-94a7-b1595125ba3a"},"_deposit":{"id":"40617","owners":[],"pid":{"revision_id":0,"type":"depid","value":"40617"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00040617","sets":["3:62:5591:606","7131:543","7131:988"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"609","bibliographicPageStart":"605","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"International immunology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田原, 聡子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"渋谷, 彰"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro. Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G+ neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae. Using Mas–TRECK mice, which is an MC deletion system based on il4 enhancer elements, we also demonstrated that Allergin-1 on MCs is responsible for the Pam2CSK4-induced ear swelling. These results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27932517","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/intimm/dxw046","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Japanese Society for Immunology. 2016. "}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0953-8178","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10730708","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsurusaki, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tahara-Hanaoka, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibagaki, Shohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyake, Shota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imai, Masamichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibayama, Shiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibuya, Akira"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-01"}],"displaytype":"detail","filename":"II_28-12.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"II_28-12","url":"https://tsukuba.repo.nii.ac.jp/record/40617/files/II_28-12.pdf"},"version_id":"3338be7c-8f04-4d67-8e00-d50c879abac3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis"}]},"item_type_id":"5","owner":"1","path":["543","988","606"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-17"},"publish_date":"2017-03-17","publish_status":"0","recid":"40617","relation_version_is_last":true,"title":["Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:08:17.086056+00:00"}