@article{oai:tsukuba.repo.nii.ac.jp:00040617,
 author = {田原, 聡子 and 渋谷, 彰 and Tsurusaki, Satoshi and Tahara-Hanaoka, Satoko and Shibagaki, Shohei and Miyake, Shota and Imai, Masamichi and Shibayama, Shiro and Kubo, Masato and Shibuya, Akira},
 issue = {12},
 journal = {International immunology},
 month = {Dec},
 note = {TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro. Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G+ neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae. Using Mas–TRECK mice, which is an MC deletion system based on il4 enhancer elements, we also demonstrated that Allergin-1 on MCs is responsible for the Pam2CSK4-induced ear swelling. These results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis.},
 pages = {605--609},
 title = {Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis},
 volume = {28},
 year = {2016}
}