{"created":"2021-03-01T07:19:16.425170+00:00","id":39948,"links":{},"metadata":{"_buckets":{"deposit":"992de147-9a1b-4983-a1b3-7b653da84a31"},"_deposit":{"id":"39948","owners":[],"pid":{"revision_id":0,"type":"depid","value":"39948"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00039948","sets":["160:1470","29:297","3:62:5297:1814"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"21","bibliographicPageEnd":"5645","bibliographicPageStart":"5639","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"臼井, 健郎"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"木越, 英夫"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50 = 2.1 μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiments of O6-benzyl glaziovianin A and revealed that O6-benzyl glaziovianin A binds to the colchicine binding site with high affinity. It is interesting that glaziovianin A derivatives change their mode of action in benzylation at the O6 (α,β-tubulin inhibitor) or O7 (γ-tubulin-specific inhibitor) position.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier "}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27665177","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bmc.2016.09.026","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©  2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ "}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09680896","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10938083","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayakawa, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shioda, Shuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chinen, Takumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatanaka, Taisei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ebisu, Haruna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakakura, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木越, 英夫"},{"creatorName":"キゴシ, ヒデオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-01"}],"displaytype":"detail","filename":"BMC_24-21.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"BMC_24-21","url":"https://tsukuba.repo.nii.ac.jp/record/39948/files/BMC_24-21.pdf"},"version_id":"5253787c-8c8b-4005-87c1-1f473e916cd4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization"}]},"item_type_id":"5","owner":"1","path":["297","1470","1814"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-26"},"publish_date":"2016-12-26","publish_status":"0","recid":"39948","relation_version_is_last":true,"title":["Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:10:16.208718+00:00"}