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Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization
http://hdl.handle.net/2241/00144698
http://hdl.handle.net/2241/001446986ab57110-699a-4a4b-86a0-048b4486c3e6
名前 / ファイル | ライセンス | アクション |
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BMC_24-21 (2.7 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-12-26 | |||||
タイトル | ||||||
タイトル | Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hayakawa, Ichiro
× Hayakawa, Ichiro× Shioda, Shuya× Chinen, Takumi× Hatanaka, Taisei× Ebisu, Haruna× Sakakura, Akira× Usui, Takeo× 木越, 英夫 |
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著者別名 |
臼井, 健郎
× 臼井, 健郎× 木越, 英夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50 = 2.1 μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiments of O6-benzyl glaziovianin A and revealed that O6-benzyl glaziovianin A binds to the colchicine binding site with high affinity. It is interesting that glaziovianin A derivatives change their mode of action in benzylation at the O6 (α,β-tubulin inhibitor) or O7 (γ-tubulin-specific inhibitor) position. | |||||
書誌情報 |
Bioorganic & Medicinal Chemistry 巻 24, 号 21, p. 5639-5645, 発行日 2016-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09680896 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10938083 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27665177 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bmc.2016.09.026 | |||||
権利 | ||||||
権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier |