{"created":"2021-03-01T07:18:53.074552+00:00","id":39587,"links":{},"metadata":{"_buckets":{"deposit":"05b8507f-30d7-44aa-9b87-dfe3669648c5"},"_deposit":{"id":"39587","owners":[],"pid":{"revision_id":0,"type":"depid","value":"39587"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00039587","sets":["2780:1781","3:62:5591:5481"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"808","bibliographicPageStart":"801","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"International journal of hyperthermia"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"櫻井, 英幸"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To evaluate the effectiveness of whole-pelvic hyperthermia (HT) added to standard chemoradiotherapy (CRT) in locally advanced cervical cancer (CC), by investigating the clinical response and survival of patients treated with cisplatin-based CRT vs. CRT with HT (CRT + HT).\n\nMaterials and methods: This study was conducted at five hospitals in Japan between September 2001 and March 2015 in patients with the International Federation of Gynecology and Obstetrics stage IB (bulky)–IVA CC undergoing definitive CRT. After giving a written informed consent, patients were randomly allocated to two treatment groups: CRT and CRT + HT group. Overall survival (OS), disease-free survival (DFS), local relapse-free survival (LRFS), complete response (CR) rate and tolerability were evaluated.\n\nResults: In total, 101 patients were treated. Patient characteristics, total dose of cisplatin and radiotherapy were similar for both groups. Although not statistically significant, the 5-year OS, DFS and LRFS in the CRT + HT group (77.8%, 70.8% and 80.1%, respectively) were better than those in the CRT group (64.8%, 60.6% and 71.0%, respectively). CR was significantly more likely to be achieved in patients in the CRT + HT group than in the CRT group (88% vs. 77.6%; adjusted odds ratio, 3.993; 95% confidence interval, 1.018–15.67; p = .047). CRT + HT was well tolerated and caused no additional acute or long-term toxicity compared with CRT alone.\n\nConclusions: HT combined with CRT improved the CR rate of CRT in patients with locally advanced CC, however, could not improve survival outcomes. Further studies in larger samples are warranted.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27418208 ","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/02656736.2016.1213430","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":" ©2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group."},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/by-ncnd/ 4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0265-6736","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10455782","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Harima, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohguri, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imada, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiraki, Yoshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tuji, Koh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terashima, Hiromi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"IJH_32-7.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"IJH_32-7","url":"https://tsukuba.repo.nii.ac.jp/record/39587/files/IJH_32-7.pdf"},"version_id":"2e736f53-bb50-41ba-9dfe-ef3310742b90"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer"}]},"item_type_id":"5","owner":"1","path":["1781","5481"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-31"},"publish_date":"2016-10-31","publish_status":"0","recid":"39587","relation_version_is_last":true,"title":["A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:07:45.121125+00:00"}