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Unraveling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach
http://hdl.handle.net/2241/00143459
http://hdl.handle.net/2241/00143459031004a2-fac5-476a-b902-48c3431dfb9d
名前 / ファイル | ライセンス | アクション |
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GD_8-139 (1.7 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-08-02 | |||||
タイトル | ||||||
タイトル | Unraveling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hori, Motohide
× Hori, Motohide× Kubo, Hiroko× Shibato, Junko× Saito, Tomomi× Ogawa, Tetsuo× Wakamori, Minoru× Masuo, Yoshinori× Shioda, Seiji× Rakwal, Randeep |
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著者別名 |
Rakwal, Randeep
× Rakwal, Randeep |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lavender oil (LO) is a commonly used essential oil in aromatherapy as non-traditional medicine. With an aim to demonstrate LO effects on the body, we have recently established an animal model investigating the influence of orally administered LO in rat tissues, genome-wide. In this brief, we investigate the effect of LO ingestion in the blood of rat. Rats were administered LO at usual therapeutic dose (5 mg/kg) in humans, and following collection of the venous blood from the heart and extraction of total RNA, the differentially expressed genes were screened using a 4 × 44-K whole-genome rat chip (Agilent microarray platform; Agilent Technologies, Palo Alto, CA, USA) in conjunction with a two-color dye-swap approach. A total of 834 differentially expressed genes in the blood were identified: 362 up-regulated and 472 down-regulated. These genes were functionally categorized using bioinformatics tools. The gene expression inventory of rat blood transcriptome under LO, a first report, has been deposited into the Gene Expression Omnibus (GEO): GSE67499. The data will be a valuable resource in examining the effects of natural products, and which could also serve as a human model for further functional analysis and investigation. | |||||
書誌情報 |
Genomics Data 巻 8, p. 139-145, 発行日 2016-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2213-5960 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27330992 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.gdata.2016.05.005 | |||||
権利 | ||||||
権利情報 | © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Elsevier |