{"created":"2021-03-01T07:17:49.292863+00:00","id":38619,"links":{},"metadata":{"_buckets":{"deposit":"47fd4dba-746f-4ae3-bb9a-a8e4dac79844"},"_deposit":{"id":"38619","owners":[],"pid":{"revision_id":0,"type":"depid","value":"38619"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00038619","sets":["160:1260","3:62:5587:2683"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6087213","bibliographicVolumeNumber":"2016","bibliographic_titles":[{"bibliographic_title":"Evidence-based complementary and alternative medicine "}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"繁森, 英幸"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy. However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required. The Paeoniaceae family is widely used in traditional Chinese medicine. We examined methanol and butanol extracts of Paeonia lutea (P. lutea) leaves for their potential as an anticancer agent. Both extracts decreased the proliferation of SCC cells, induced apoptotic cell death, and modulated migration, adhesion, chemotaxis, and haptotaxis in an extracellular matrix- (ECM-) dependent manner due to altered expression of several integrin subunits. Subsequently, SCC cells were subcutaneously transplanted into athymic nude mice; the extracts reduced the metastasis of SCC cells but had little effect on the volume of the primary tumor or survival or body weight of the mice. The results suggest that the extracts may hold promise for preventing cancer metastasis.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi Publishing Corporation"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2016/6087213","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2016 Yoshiki Mukudai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":" 1741-427X ","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mukudai, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Meilin "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiogama, Sunao "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Seiji "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Chihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motohashi, Hiromi "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Kosuke "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Miharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shintani, Satoru "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shigemori, Hideyuki "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yazawa, Kazunaga "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirota, Tatsuo "}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-19"}],"displaytype":"detail","filename":"E-BCAM_2016.pdf","filesize":[{"value":"4.0 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"E-BCAM_2016","url":"https://tsukuba.repo.nii.ac.jp/record/38619/files/E-BCAM_2016.pdf"},"version_id":"72629662-21a7-4a31-9374-e9af7fe91c09"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma"}]},"item_type_id":"5","owner":"1","path":["1260","2683"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-19"},"publish_date":"2016-07-19","publish_status":"0","recid":"38619","relation_version_is_last":true,"title":["Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:08:29.347781+00:00"}