{"created":"2021-03-01T07:17:32.047630+00:00","id":38361,"links":{},"metadata":{"_buckets":{"deposit":"cee2fa14-37ad-4347-a1b5-3d42f64a28e8"},"_deposit":{"id":"38361","owners":[],"pid":{"revision_id":0,"type":"depid","value":"38361"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00038361","sets":["2780:2179","2780:5273","2780:5274","2780:5275","2780:5276","3:62:5592:5272"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"e3","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Journal of gynecologic oncology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小貫, 麻美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"櫻井, 学"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"越智, 寛幸"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"水口, 剛雄"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"佐藤, 豊実"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Objective\nWe conducted a pooled analysis of published studies to compare the performance of human papillomavirus (HPV) testing and cytology in detecting residual or recurrent diseases after treatment for cervical intraepithelial neoplasia grade 2 or 3 (CIN 2/3).\nMethods\nSource articles presenting data on posttreatment HPV testing were identified from the National Library of Medicine (PubMed) database. We included 5,319 cases from 33 articles published between 1996 and 2013.\nResults\nThe pooled sensitivity of high-risk HPV testing (0.92; 95% confidence interval [CI], 0.90 to 0.94) for detecting posttreatment CIN 2 or worse (CIN 2+) was much higher than that of cytology (0.76; 95% CI, 0.71 to 0.80). Co-testing of HPV testing and cytology maximized the sensitivity (0.93; 95% CI, 0.87 to 0.96), while HPV genotyping (detection of the same genotype between pre- and posttreatments) did not improve the sensitivity (0.89; 95% CI, 0.82 to 0.94) compared with high-risk HPV testing alone. The specificity of high-risk HPV testing (0.83; 95% CI, 0.82 to 0.84) was similar to that of cytology (0.85; 95% CI, 0.84 to 0.87) and HPV genotyping (0.83; 95% CI, 0.81 to 0.85), while co-testing had reduced specificity (0.76; 95% CI, 0.75 to 0.78). For women with positive surgical margins, high-risk HPV testing provided remarkable risk discrimination between test-positives and test-negatives (absolute risk of residual CIN 2+ 74.4% [95% CI, 64.0 to 82.6] vs. 0.8% [95% CI, 0.15 to 4.6]; p<0.001).\nConclusion\nOur findings recommend the addition of high-risk HPV testing, either alone or in conjunction with cytology, to posttreatment surveillance strategies. HPV testing can identify populations at greatest risk of posttreatment CIN 2+ lesions, especially among women with positive section margins.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Asian Society of Gynecologic Oncology"},{"subitem_publisher":"Korean Society of Gynecologic Oncology"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26463429","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3802/jgo.2016.27.e3","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2016. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology"},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2005-0380","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Onuki, Mamiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ochi, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minaguchi, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Toyomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Hiroyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-06-28"}],"displaytype":"detail","filename":"JGO_27-1.pdf","filesize":[{"value":"328.1 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"JGO_27-1","url":"https://tsukuba.repo.nii.ac.jp/record/38361/files/JGO_27-1.pdf"},"version_id":"a6921e75-47d5-49c8-824c-2f27a73650ea"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Posttreatment human papillomavirus testing for residual or recurrent high-grade cervical intraepithelial neoplasia: a pooled analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Posttreatment human papillomavirus testing for residual or recurrent high-grade cervical intraepithelial neoplasia: a pooled analysis"}]},"item_type_id":"5","owner":"1","path":["5275","5273","5274","2179","5276","5272"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-06-28"},"publish_date":"2016-06-28","publish_status":"0","recid":"38361","relation_version_is_last":true,"title":["Posttreatment human papillomavirus testing for residual or recurrent high-grade cervical intraepithelial neoplasia: a pooled analysis"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:08:06.898115+00:00"}