{"created":"2021-03-01T07:17:31.447442+00:00","id":38352,"links":{},"metadata":{"_buckets":{"deposit":"33cd0f23-84ed-448e-9149-060629798913"},"_deposit":{"id":"38352","owners":[],"pid":{"revision_id":0,"type":"depid","value":"38352"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00038352","sets":["2778:1984","3:62:5596:5259"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"145","bibliographicPageStart":"135","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Neuropathology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水上, 勝義"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Studies of acetylcholine degrading enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in Alzheimer's disease (AD) have suggested their potential role in the development of fibrillar amyloid-β (Aβ) plaques (amyloid plaques). A recent genome-wide association study analysis identified a novel association between genetic variations in the BCHE locus and amyloid burden. We studied BChE immunoreactivity in hippocampal tissue sections from AD and control cases, and examined its relationship with amyloid plaques, neurofibrillary tangles (NFT), dystrophic neurites (DN) and neuropil threads (NT). Compared to controls, AD cases had greater BChE immunoreactivity in hippocampal neurons and neuropils in CA2/3, but not in the CA1, CA4 and dentate gyrus. The majority of amyloid plaques (> 80%, using a pan-amyloid marker X-34) contained discrete neuritic clusters which were dual-labeled with antibodies against BChE and phosphorylated tau (clone AT8). There was no association between overall regional BChE immunoreaction intensity and amyloid plaque burden. In contrast to previous reports, BChE was localized in only a fraction (~10%) of classic NFT (positive for X-34). A similar proportion of BChE-immunoreactive pyramidal cells were AT8 immunoreactive. Greater NFT and DN loads were associated with greater BChE immunoreaction intensity in CA2/3, but not in CA1, CA4 and dentate gyrus. Our results demonstrate that in AD hippocampus, BChE accumulates in neurons and plaque-associated neuritic clusters, but only in a small proportion of NFT. The association between greater neurofibrillary pathology burden and markedly increased BChE immunoreactivity, observed selectively in CA2/3 region, could reflect a novel compensatory mechanism. Since CA2/3 is generally considered more resistant to AD pathology, BChE upregulation could impact the cholinergic modulation of glutamate neurotransmission to prevent/reduce neuronal excitotoxicity in AD hippocampus.","subitem_description_type":"Abstract"}]},"item_5_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This articles partially phrase has been edited after the publicatoin.\nIn the current published version, the flollowing sentence has been added.\n(page 137, left column, line 4)\n\n[Correction added on 25 September, 2015, after first online publication: The following phrase has been edited:‘three sections from each Fisher Scientific case’has been corrected to‘three sections from each case’in the above sentence.]","subitem_description_type":"Other"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":" Wiley"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26293308","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/neup.12241","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 Japanese Society of Neuropathology"},{"subitem_rights":"This is the peer reviewed version of the following article: Neuropathology Volume 36, Issue 2, pages 135-145, April 2016, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/neup.12241. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-6544","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11009964","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mizukami, Katsuyoshi "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akatsu, Hiroyasu "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abrahamson, Eric E. "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mi, Zhiping "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":" Ikonomovic, Milos D."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-01"}],"displaytype":"detail","filename":"Neuropathology 36-2.pdf","filesize":[{"value":"5.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Neuropathology 36-2","url":"https://tsukuba.repo.nii.ac.jp/record/38352/files/Neuropathology 36-2.pdf"},"version_id":"3311c228-000f-4b53-a679-c5b09afd4963"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease"}]},"item_type_id":"5","owner":"1","path":["1984","5259"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-06-27"},"publish_date":"2016-06-27","publish_status":"0","recid":"38352","relation_version_is_last":true,"title":["Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:08:06.600776+00:00"}