{"created":"2021-03-01T07:17:24.946311+00:00","id":38245,"links":{},"metadata":{"_buckets":{"deposit":"bb41ecc4-6d06-43ba-b19e-80eaa8181015"},"_deposit":{"id":"38245","owners":[],"pid":{"revision_id":0,"type":"depid","value":"38245"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00038245","sets":["2780:1495","2780:1501","2780:1639975837591","2780:171","2780:2762","2780:5141","3:62:5592:5140"]},"author_link":["204212","546","108108","97","662"],"control_number":"38245","item_1644910766877":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"255","bibliographicPageStart":"248","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Journal of oral pathology & medicine","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background<br/>Abnormal miRNA expression was recently implicated in the metastasis of oral squamous cell carcinoma (OSCC) and with a poor prognosis. The initiation of the invasion-metastasis cascade involves epithelial-mesenchymal transition (EMT). Our aim was to clarify how miRNA, especially miR-155-5p misexpression contributes to OSCC metastasis through EMT.<br/><br/>Methods<br/>We collected tumor samples from 73 subjects with OSCC. The samples were analyzed by quantitative reverse-transcription polymerase chain reaction (qRT-PCR), and correlations between miR-155-5p levels and clinical characteristics were investigated. OSCC cell lines were analyzed by miRNA microarray and by transfection with a miR-155-5p mimic or inhibitor, followed by proliferation and wound-healing migration assays. qRT-PCR analyses of EMT makers in cells transfected with miR-155-5p inhibitor were performed.<br/><br/>Results<br/>We found high miR-155-5p expression in tissue samples from subjects with OSCC that had metastasized to cervical lymph nodes. HSC-3 cells also strongly expressed miR-155-5p. The epithelial marker E-cadherin was strongly expressed in HSC-3 cells transfected with miR-155-5p inhibitor, and we observed elevated SOCS1 and decreased STAT3 expression in these cells.<br/><br/>Conclusions<br/>Our results suggest that miR-155-5p causes OSCC to metastasize, and could serve as a novel therapeutic target for OSCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Ltd","subitem_publisher_language":"en"},{"subitem_publisher":"Journal of Oral Pathology & Medicine is  the official publication of the International Association of Oral Pathologists, British Society for Oral Medicine, British Society of Oral and Maxillofacial Pathology, Scandinavian Fellowship of Oral Pathology and Oral Medicine, and Japanese Society of Oral Pathology.","subitem_publisher_language":"en"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26307116","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/jop.12351","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd","subitem_rights_language":"en"},{"subitem_rights":"This is the peer reviewed version of the following article: J Oral Pathol Med (2016) 45: 248-255, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/jop.12351/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.","subitem_rights_language":"en"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0904-2512","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10715555","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Baba, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hasegawa, Shogo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagai, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"内田, 文彦","creatorNameLang":"ja"},{"creatorName":"ウチダ, フミヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"UCHIDA, Fumihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamatoji, Masanobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"菅野, 直美","creatorNameLang":"ja"},{"creatorName":"カンノ, ナオミ","creatorNameLang":"ja-Kana"},{"creatorName":"KANNO, Naomi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"山縣, 憲司","creatorNameLang":"ja"},{"creatorName":"ヤマガタ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"YAMAGATA, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"酒井, 俊","creatorNameLang":"ja"},{"creatorName":"サカイ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"SAKAI, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"柳川, 徹","creatorNameLang":"ja"},{"creatorName":"ヤナガワ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"YANAGAWA, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"武川, 寛樹","creatorNameLang":"ja"},{"creatorName":"ブカワ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"BUKAWA, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-01"}],"displaytype":"detail","filename":"JOPM_45-4.pdf","filesize":[{"value":"775.0 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"JOPM_45-4","objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/38245/files/JOPM_45-4.pdf"},"version_id":"f0fd7c01-47c6-4881-8e9e-daf6a8f8a616"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["5140","1639975837591","2762","5141","1501","171","1495"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-09"},"publish_date":"2016-06-09","publish_status":"0","recid":"38245","relation_version_is_last":true,"title":["MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-08-04T06:42:16.814457+00:00"}