{"created":"2021-03-01T07:17:24.813792+00:00","id":38243,"links":{},"metadata":{"_buckets":{"deposit":"43dc8724-0a90-43d6-b04d-5161f3f6de3b"},"_deposit":{"id":"38243","owners":[],"pid":{"revision_id":0,"type":"depid","value":"38243"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00038243","sets":["2780:2180","2780:5144","3:62:5297:5193"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"888","bibliographicPageStart":"881","bibliographicVolumeNumber":"114","bibliographic_titles":[{"bibliographic_title":"British journal of cancer"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五所, 正彦"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"森脇, 俊和"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"兵頭, 一之介"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:  \nThe need to promote novel drug development for advanced biliary tract cancer (ABTC) has emphasised the importance of determining whether various efficacy end points can act as surrogates for overall survival (OS).\nMethods:  \nWe conducted a literature search of randomised trials of first-line chemotherapy for ABTC and investigated correlations between efficacy end points and OS using weighted linear regression analysis. The ratios of the median OS, median progression-free survival (PFS), response rate, and disease control rate in each trial were used to summarise treatment effects. The surrogate threshold effect (STE), which was the minimum treatment effect on PFS required to predict a non-zero treatment effect on OS, was calculated.\nResults:  \nSeventeen randomised trials with 36 treatment arms were identified, and a sample size of 2148 patients with 19 paired arms was analysed. The strongest correlation between all evaluated efficacy end points was observed between median OS and median PFS ratios (r2=0.66). In trials with gemcitabine-containing therapies and targeted agents, the r2-values were 0.78. The STE was estimated at 0.83 for all trials and 0.81 for trials with gemcitabine-containing therapies, and was not calculated for trials with targeted agents.\nConclusions:  \nThe median PFS ratio correlated well with the median OS ratio, and may be useful for planning a clinical trial for novel drug development.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/bjc.2016.83","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":" © 2016 Cancer Research UK "},{"subitem_rights":"This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 4.0 International License. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-sa/4.0/"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0007-0920","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00574355","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Yoshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugaya, Akinori "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":" Moriwaki, Toshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":" Gosho, Masahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":" Hyodo, Ichinosuke"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-06-08"}],"displaytype":"detail","filename":"BJC 114-8.pdf","filesize":[{"value":"775.1 kB"}],"format":"application/pdf","licensetype":"license_10","mimetype":"application/pdf","url":{"label":"BJC 114-8","url":"https://tsukuba.repo.nii.ac.jp/record/38243/files/BJC 114-8.pdf"},"version_id":"a9249260-e115-4e73-a9f1-4bea653adcfa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Correlations of survival with progression-free survival, response rate, and disease control rate in advanced biliary tract cancer: a meta-analysis of randomised trials of first-line chemotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Correlations of survival with progression-free survival, response rate, and disease control rate in advanced biliary tract cancer: a meta-analysis of randomised trials of first-line chemotherapy"}]},"item_type_id":"5","owner":"1","path":["3074","2180","5144","5193"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-06-10"},"publish_date":"2016-06-10","publish_status":"0","recid":"38243","relation_version_is_last":true,"title":["Correlations of survival with progression-free survival, response rate, and disease control rate in advanced biliary tract cancer: a meta-analysis of randomised trials of first-line chemotherapy"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:07:58.054452+00:00"}