{"created":"2021-03-01T07:15:34.465007+00:00","id":36553,"links":{},"metadata":{"_buckets":{"deposit":"8883ad15-37a4-42bb-88f5-6b40e2851197"},"_deposit":{"id":"36553","owners":[],"pid":{"revision_id":0,"type":"depid","value":"36553"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00036553","sets":["2780:541","3:62:5589:70"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"600","bibliographicPageStart":"590","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Genes to cells"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 麻己人"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The induction of the gene encoding heme oxygenase 1 (Hmox1, HO-1) by Nrf2 is unique compared with other Nrf2 targets. We previously showed that the Nrf2a-mediated induction of zebrafish hmox1a was liver specific and transient. We screened transcription factors that could repress the induction of hmox1a but not other Nrf2a targets and concluded that Bach1b was a prime candidate. In bach1b-knocked-down larvae, the induction of hmox1a was observed ectopically in nonliver tissues and persisted longer than normal fish, suggesting that Bach1 is the only regulator for both the liver-specific and transient induction of hmox1a. Co-knockdown of bach1b with its co-ortholog bach1a enhanced these effects. To determine why Bach1 could not repress the hmox1a induction in the liver, we analyzed the effects of a heme biosynthesis inhibitor, succinylacetone, and a heme precursor, hemin. Succinylacetone decreased the Nrf2a-mediated hmox1a induction, whereas pre-treatment with hemin caused ectopic induction of hmox1a in nonliver tissues, implying that the high heme levels in the liver may release the repressive activity of Bach1. Our results suggested that Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25982796","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/gtc.12249","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 The Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd Ltd. This is the peer reviewed version of the following article: Genes to Cells,20,4,2015, which has been published in final form at DOI: 10.1111/gtc.12222. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. "}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1356-9597","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11078945","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fuse, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Hitomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima-Takagi, Yaeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Makoto"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"GC_20-7.pdf","filesize":[{"value":"6.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"GC_20-7","url":"https://tsukuba.repo.nii.ac.jp/record/36553/files/GC_20-7.pdf"},"version_id":"16c7deee-afa4-42e9-8c94-9850002d9827"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"GC_20-7-SI.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"GC_20-7-SI","url":"https://tsukuba.repo.nii.ac.jp/record/36553/files/GC_20-7-SI.pdf"},"version_id":"0713a409-1513-4fc1-bb30-faddbb454fe5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1"}]},"item_type_id":"5","owner":"1","path":["541","70"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-08"},"publish_date":"2016-01-08","publish_status":"0","recid":"36553","relation_version_is_last":true,"title":["Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:05:38.621934+00:00"}