@article{oai:tsukuba.repo.nii.ac.jp:00035791, author = {中嶋, 光敏 and Khalid, Nauman and Kobayashi, Isao and Neves, Marcos A. and Uemura, Kunihiko and Nakajima, Mitsutoshi and Nabetani, Hiroshi}, issue = {6}, journal = {Journal of microencapsulation}, month = {Jul}, note = {Monodisperse aqueous microspheres containing high concentrations of l-ascorbic acid with different concentrations of sodium alginate (Na-ALG) and magnesium sulfate (MgSO4) were prepared by using microchannel emulsification (MCE). The continuous phase was water-saturated decane containing a 5% (w/w) hydrophobic emulsifier. The flow rate of the continuous phase was maintained at 10 mL h−1, whereas the pressure applied to the disperse phase was varied between 3 and 25 kPa. The disperse phase optimized for successfully generating aqueous microspheres included 2% (w/w) Na-ALG and 1% (w/w) MgSO4. At a higher MgSO4 concentration, the generated microspheres resulted in coalescence and subsequent bursting. At a lower MgSO4 concentration, unstable and polydisperse microspheres were obtained. The aqueous microspheres generated from the MCs under optimized conditions had a mean particle diameter (dav) of 14–16 µm and a coefficient of variation (CV) of less than 8% at the disperse phase pressures of 5–15 kPa.}, pages = {570--577}, title = {Preparation of monodisperse aqueous microspheres containing high concentration of l-ascorbic acid by microchannel emulsification}, volume = {32}, year = {2015} }