{"created":"2021-03-01T07:12:22.790007+00:00","id":33593,"links":{},"metadata":{"_buckets":{"deposit":"ce8de09d-bba5-40d8-94d8-7c4c817269f2"},"_deposit":{"id":"33593","owners":[],"pid":{"revision_id":0,"type":"depid","value":"33593"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00033593","sets":["2780:1292","3:62:5611:3042"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"140","bibliographicPageStart":"134","bibliographicVolumeNumber":"476","bibliographic_titles":[{"bibliographic_title":"Virology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹内, 薫"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bovine parainfluenza virus type 3 (BPIV3) is an important pathogen associated with bovine respiratory disease complex (BRDC). We have generated a recombinant BPIV3 expressing enhanced green fluorescent protein (rBPIV3-EGFP) based on the BN-1 strain isolated in Japan. After intranasal infection of hamsters with rBPIV3-EGFP, EGFP fluorescence was detected in the upper respiratory tract including the nasal turbinates, pharynx, larynx, and trachea. In the nasal turbinates, rBPIV3-EGFP attained high titers (>106 TCID50/g of tissue) 2–4 days after infection. Ciliated epithelial cells in the nasal turbinates and trachea were infected with rBPIV3-EGFP. Histopathological analysis indicated that mucosal epithelial cells in bronchi were shed by 6 days after infection, leaving non-ciliated cells, which may have increased susceptibility to bacterial infection leading to the development of BRDC. These data indicate that rBPIV3-EGFP infection of hamsters is a useful small animal model for studying the development of BPIV3-associated BRDC.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25543964","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.virol.2014.12.015","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 Elsevier Inc."},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in Virology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Virology, 476, 2015, DOI:10.1016/j.virol.2014.12.015"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0042-6822","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00884454","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohkura, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minakuchi, Moeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sagai, Mami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kokuho, Takehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Konishi, Misako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kameyama, Ken-ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeuchi, Kaoru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-04-30"}],"displaytype":"detail","filename":"Virology_476.pdf","filesize":[{"value":"802.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Virology_476","url":"https://tsukuba.repo.nii.ac.jp/record/33593/files/Virology_476.pdf"},"version_id":"7334c3a6-fda1-4d7c-8ea5-33a03d00f40d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein"}]},"item_type_id":"5","owner":"1","path":["1292","3042"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-30"},"publish_date":"2015-04-30","publish_status":"0","recid":"33593","relation_version_is_last":true,"title":["Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2023-07-12T06:01:37.121269+00:00"}