{"created":"2021-03-01T07:10:21.539314+00:00","id":31691,"links":{},"metadata":{"_buckets":{"deposit":"368a3eb6-2b3e-4582-a823-346c9df79b4c"},"_deposit":{"id":"31691","owners":[],"pid":{"revision_id":0,"type":"depid","value":"31691"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00031691","sets":["2770:2773","3:62:5297:1319"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageEnd":"4898","bibliographicPageStart":"4895","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Bioorganic & medicinal chemistry letters "}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長瀬, 博"}],"nameIdentifiers":[{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We designed and synthesized of 1,3,5-trioxazatriquinanes with o- or p-hydroxyphenyl rings as analogs of the κ opioid receptor agonist SYK-146 with m-hydroxyphenyl groups. Although almost all tested compounds did not bind to the opioid receptors, only 17b (SYK-524) with two o-hydroxyphenyl rings showed moderate or potent binding affinities and exhibited agonistic activities for the three opioid receptor types. Because the basicity of the nitrogen atom in the 1,3,5-trioxazatriquinane structure was predicted to be very low due to the electron withdrawing effect of the three oxygen atoms, SYK-524 was a novel non-morphinan and nonpeptidic opioid universal agonist lacking a basic nitrogen atom.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25248680","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bmcl.2014.08.012","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 Elsevier Ltd."},{"subitem_rights":" \"NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic & medicinal chemistry letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bioorganic & medicinal chemistry letters 24,20,2014. doi:10.1016/j.bmcl.2014.08.012 \""}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1079577X","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirayama, Shigeto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wada, Naohisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuroda, Naoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwai, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaotsu, Noriyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirono, Shuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagase, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-11-14"}],"displaytype":"detail","filename":"BMCL_24-20.pdf","filesize":[{"value":"258.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCL_24-20","url":"https://tsukuba.repo.nii.ac.jp/record/31691/files/BMCL_24-20.pdf"},"version_id":"38c47c1f-621c-4c95-8340-c2546ab649f2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies"}]},"item_type_id":"5","owner":"1","path":["2773","1319"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-14"},"publish_date":"2014-11-14","publish_status":"0","recid":"31691","relation_version_is_last":true,"title":["Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T08:59:56.499647+00:00"}