@article{oai:tsukuba.repo.nii.ac.jp:00031293, author = {竹田, 一則 and Yonekura, Takashi and Takeda, Kazunori and Shetty, Vivek and Yamaguchi, Masaki}, issue = {4}, journal = {The journal of physiological sciences}, month = {Jul}, note = {The purpose of this study was to determine the utility of salivary cortisol levels for screening mental states such as depression in adolescents following a natural disaster. We examined the relationship of salivary cortisol levels in adolescent survivors of the 2011 Tohoku Earthquake with the depression subscale of the 28-item General Health Questionnaire (GHQ). Subjects were 63 adolescent survivors (age = 14.29 years ± 0.51) who were administered the GHQ and provided saliva samples thrice daily (morning, afternoon and evening) over the course of 3 days. Based on the GHQ-depression subscores, subjects were divided into low and high depression groups. About 22 % of the subjects were classified into the high symptom group. When data collected over 3 days were used, a significant difference was observed between the two groups in the salivary cortisol levels at the evening time point as well the ratio of the morning/evening levels (p < 0.05). Analyzed by means of receiver-operating characteristic curves, the morning/evening ratios showed a good power in discriminating between subjects with and without depressive symptoms. Our study suggests that repeated measurement of salivary cortisol levels over 3 days has utility in screening for depressive states in adolescents following a natural disaster.}, pages = {261--267}, title = {Relationship between salivary cortisol and depression in adolescent survivors of a major natural disaster}, volume = {64}, year = {2014} }