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Dependence of ethanol effects on protein charges
http://hdl.handle.net/2241/00121953
http://hdl.handle.net/2241/0012195391e5ba74-f9c4-4b92-ae03-8b9065218ed6
名前 / ファイル | ライセンス | アクション |
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IJBM_68.pdf (1.3 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2014-08-18 | |||||
タイトル | ||||||
タイトル | Dependence of ethanol effects on protein charges | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yoshizawa, Shunsuke
× Yoshizawa, Shunsuke× Arakawa, Tsutomu× Shiraki, Kentaro |
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著者別名 |
白木, 賢太郎
× 白木, 賢太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ethanol is used as a conventional disinfectant solution. It is highly effective against enveloped viruses due to its effects on virus membranes. It also confers inactivation of non-enveloped viruses, which can be ascribed to conformational changes or changes in association state of the viral proteins induced by ethanol. We have examined here the effects of pH and hence the charged state of proteins on the ethanol-induced conformational changes and self-association of model proteins, i.e., bovine serum albumin (BSA) and ribonuclease A (RNase A). Both proteins showed qualitatively different aggregation behavior and structure changes by ethanol at pH 4.0 and 7.0, at which BSA has opposite charges and RNase A has different degree of net positive charges. | |||||
書誌情報 |
International journal of biological macromolecules 巻 68, p. 169-172, 発行日 2014-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0141-8130 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1153092X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24780565 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijbiomac.2014.04.041 | |||||
権利 | ||||||
権利情報 | © 2014 Elsevier B.V. NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Biological Macromolecules. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Biological Macromolecules, 68, 2014, http://dx.doi.org/10.1016/j.ijbiomac.2014.04.041. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | ELSEVIER |