{"created":"2021-03-01T07:09:36.178976+00:00","id":30982,"links":{},"metadata":{"_buckets":{"deposit":"ab0f1f84-3c33-40d1-a16d-dfe8adf2b2ad"},"_deposit":{"id":"30982","owners":[],"pid":{"revision_id":0,"type":"depid","value":"30982"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00030982","sets":["160:852","3:62:5298:2737"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"32","bibliographicPageStart":"26","bibliographicVolumeNumber":"170","bibliographic_titles":[{"bibliographic_title":"Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂本, 和一"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Many studies on thermotolerance have been done in Caenorhabditis elegans in order to extend survival under heat stress; Daf-16, a homolog of FoxO in C. elegans, was detected as the key factor in thermotolerance. However, the recovery process from heat stress damage has been seldom discussed. In this study, we analyzed the roles of FoxO/Daf-16 on the recovery from heat stress damage by monitoring thrashing movement. Heat shock reduced the movement, which was restored by culturing at 20 °C. Thrashing movement was not restored in the daf-16 mutant, which suggests that Daf-16 is one of the essential factors in repairing the damage. Movement restoration was promoted in the daf-2 mutant, a homolog of insulin/IGF-1-like receptor, in a daf-16-dependent manner. In addition, heat stress decreased the expression of daf-28 and ins-7, agonists of Daf-2. Taken together, these results revealed that FoxO/Daf-16 removes heat stress damage and restores movement via inhibition of the insulin-like signaling pathway in C. elegans, suggesting that FoxO/Daf-16 plays a critical role in thermotolerance.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24472780","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.cbpb.2014.01.004","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 Elsevier Inc.　NOTICE: this is the author’s version of a work that was accepted for publication in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, 170, 2014, DOI:10.1016/j.cbpb.2014.01.004"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1096-4959","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11525249","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Furuhashi, Tsubasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Kazuichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-06-20"}],"displaytype":"detail","filename":"CBP-B_170.pdf","filesize":[{"value":"387.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CBP-B_170","url":"https://tsukuba.repo.nii.ac.jp/record/30982/files/CBP-B_170.pdf"},"version_id":"b7418e88-36c0-4a55-88ea-05dbea578df4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"FoxO/Daf-16 restored thrashing movement reduced by heat stress in Caenorhabditis elegans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"FoxO/Daf-16 restored thrashing movement reduced by heat stress in Caenorhabditis elegans"}]},"item_type_id":"5","owner":"1","path":["852","2737"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-20"},"publish_date":"2014-06-20","publish_status":"0","recid":"30982","relation_version_is_last":true,"title":["FoxO/Daf-16 restored thrashing movement reduced by heat stress in Caenorhabditis elegans"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T08:59:37.526397+00:00"}