@article{oai:tsukuba.repo.nii.ac.jp:00030856,
 author = {Nabekura, Tsukasa and Kanaya, Minoru and Shibuya, Akira and 渋谷, 彰 and Fu, Guo and Gascoigne, Nicholas R.J. and Lanier, Lewis L.},
 issue = {2},
 journal = {Immunity},
 month = {Feb},
 note = {Recent studies demonstrate that natural killer (NK) cells have adaptive immune features. Here, we investigated the role of the costimulatory molecule DNAM-1 in the differentiation of NK cells in a mouse model of cytomegalovirus (MCMV) infection. Antibody blockade of DNAM-1 suppressed the expansion of MCMV-specific Ly49H+ cells during viral infection and inhibited the generation of memory NK cells. Similarly, DNAM-1-deficient (Cd226−/−) Ly49H+ NK cells exhibited intrinsic defects in expansion and differentiation into memory cells. Src-family tyrosine kinase Fyn and serine-threonine protein kinase C isoform eta (PKCη) signaling through DNAM-1 played distinct roles in the generation of MCMV-specific effector and memory NK cells. Thus, cooperative signaling through DNAM-1 and Ly49H are required for NK cell-mediated host defense against MCMV infection.},
 pages = {225--234},
 title = {Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection},
 volume = {40},
 year = {2014}
}