{"created":"2021-03-01T07:07:59.734685+00:00","id":29501,"links":{},"metadata":{"_buckets":{"deposit":"fc5f9661-3989-4767-b6a1-1ac94e050b25"},"_deposit":{"id":"29501","owners":[],"pid":{"revision_id":0,"type":"depid","value":"29501"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00029501","sets":["2780:2611","2780:2616","2780:2618","2871:2876:2617","3:62:5598:2566"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"526","bibliographicPageStart":"521","bibliographicVolumeNumber":"209","bibliographic_titles":[{"bibliographic_title":"Pathology, research and practice"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"里見, 介史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴, 綾"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"菅野, 雅人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野口, 雅之"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Atypical teratoid/rhabdoid tumor (AT/RT) is a rhabdoid tumor of the central nervous system comprising a mixture of small round cells and mesenchymal and/or epithelial elements, showing mutation of the SMARCB1 gene or SMARCA4 gene. The epidermal growth factor receptor (EGFR) is one of the tyrosine kinase receptors whose overexpressed protein plays important roles in the malignant characteristics of various tumors. We analyzed 8 Japanese cases of AT/RT for EGFR protein overexpression and egfr gene amplification using immunohistochemistry and fluorescence in situ hybridization. The patients included 7 boys and 1 girl (age range 13 days to 2 years), and the tumors were localized in the frontal lobe (1 case), lateral ventricle (1 case), third ventricle (1 case), fourth ventricle (3 cases), and cerebellum (2 cases). We found that all (100%) of them partially expressed a high level of EGFR protein, and that one case showed amplification of egfr, the amplified area being localized and limited to a specific area within the tumor. We speculate that AT/RT is a tumor with heterogeneous egfr amplification, and that the frequency of amplification may depend on loss of function of the specific chromatin-remodeling member.","subitem_description_type":"Abstract"}]},"item_5_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/120753"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23880166","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.prp.2013.06.007","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 Elsevier GmbH. NOTICE: this is the author’s version of a work that was accepted for publication in Pathology - Research and Practice. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pathology - Research and Practice, 209, 8, 2013, http://dx.doi.org/10.1016/j.prp.2013.06.007."}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0344-0338","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satomi, Kaishi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morishita, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murata, Yoshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiba-Ishii, Aya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugano, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noguchi, Masayuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-05-09"}],"displaytype":"detail","filename":"PRP_209-8.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PRP_209-8.pdf","url":"https://tsukuba.repo.nii.ac.jp/record/29501/files/PRP_209-8.pdf"},"version_id":"6f9c66b8-1907-445c-9b32-80e6935afbd2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Epidermal growth factor receptor abnormalities in atypical teratoid/rhabdoid tumors and an unusual case with gene amplification","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Epidermal growth factor receptor abnormalities in atypical teratoid/rhabdoid tumors and an unusual case with gene amplification"}]},"item_type_id":"5","owner":"1","path":["2611","2616","2618","2617","2566"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-10"},"publish_date":"2014-02-10","publish_status":"0","recid":"29501","relation_version_is_last":true,"title":["Epidermal growth factor receptor abnormalities in atypical teratoid/rhabdoid tumors and an unusual case with gene amplification"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T08:57:59.485972+00:00"}