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Involvement of Fcα/μR (CD351) in autoantibody production
http://hdl.handle.net/2241/120664
http://hdl.handle.net/2241/12066445827897-f370-4d1f-9d0e-4873f5f3cce2
名前 / ファイル | ライセンス | アクション |
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MI_57-2pdf.pdf (612.6 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2014-02-03 | |||||
タイトル | ||||||
タイトル | Involvement of Fcα/μR (CD351) in autoantibody production | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yoshizawa, Yuichi
× Yoshizawa, Yuichi× Honda, Shin-ichiro× Shibuya, Akira |
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著者別名 |
本多, 伸一郎
× 本多, 伸一郎× 渋谷, 彰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Faslpr/lpr (Fcamr−/−Faslpr/lpr) mice. Fcamr−/−Faslpr/lpr mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr+/+Faslpr/lpr mice. Moreover, Fcamr−/−Faslpr/lpr mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr+/+Faslpr/lpr mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production. | |||||
書誌情報 |
Molecular immunology 巻 57, 号 2, p. 216-219, 発行日 2014-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0161-5890 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00307483 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24172225 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.molimm.2013.10.002 | |||||
権利 | ||||||
権利情報 | © 2014 Elsevier Ltd. NOTICE: this is the author’s version of a work that was accepted for publication in Molecular immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular immunology, 57, 2, 2014, http://dx.doi.org/10.1016/j.molimm.2013.10.002. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/120664 | |||||
識別子タイプ | HDL |