WEKO3
アイテム
{"_buckets": {"deposit": "dd063834-ad5b-46f4-8cc8-45120e357b7a"}, "_deposit": {"id": "29429", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "29429"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00029429", "sets": ["1789", "2562"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "367", "bibliographicPageStart": "362", "bibliographicVolumeNumber": "22", "bibliographic_titles": [{"bibliographic_title": "Melanoma research"}]}]}, "item_5_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "藤澤, 康弘"}], "nameIdentifiers": [{"nameIdentifier": "573", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70550193", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000070550193"}, {"nameIdentifier": "0000002388", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000002388"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The benefit of a sentinel lymph node (SLN) biopsy and adjuvant therapy for patients with thick (\u003e4 mm) melanoma has not been well studied in the Asian population. We examined the benefit of an SLN biopsy and adjuvant therapy on prognosis in Japanese patients with thick melanoma. A review of the melanoma database collected from 26 institutions in Japan identified 291 patients with thick melanoma between 2005 and 2010. Univariate and multivariate analyses were performed to evaluate the factors predictive of the overall survival (OS) and the disease-free survival (DFS). Of the 242 patients with thick melanoma who underwent an SLN biopsy, the results for 96 (40%) were positive. On multivariate analysis, increased Breslow thickness (relative risk, 1.11; 95% confidence interval, 1.05–1.17; P=0.0002) and SLN metastasis (2.14; 1.04–4.43; P=0.040) were associated with a poor OS. Increased Breslow thickness (1.11; 1.04–1.18; P =0.0018), ulceration (3.11; 1.25–7.72; P=0.014), satellitosis (3.89; 1.62–9.31; P=0.0023), and SLN metastasis (2.24; 1.16–4.36; P=0.017) were associated with DFS. Adjuvant chemotherapy had no impact on either OS or DFS. Adjuvant use of a monthly dermal injection of interferon-β (IFN-β) was associated with a improvement in both OS (0.34; 0.17–0.67; P=0.0022) and DFS (0.42; 0.20–0.86; P=0.018). An SLN biopsy provided useful prognostic information and the adjuvant use of IFN-β improved both OS and DFS in Japanese patients with thick melanoma. These results were consistent with those of previous studies carried out on a white population. Therefore, we suggest that an SLN biopsy and adjuvantIFN should be considered for patients with thick melanoma irrespective of the Breslow thickness or ethnicity.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/120038"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Lippincott Williams \u0026 Wilkins, Inc."}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "22713797", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1097/CMR.0b013e328355e558", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2012 Lippincott Williams \u0026 Wilkins, Inc.\nThis is a non-final version of an article published in final form in Melanoma Research, Vol 22, Issue 5, Oct. 2012."}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1473-5636", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12569793", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NIIサブジェクト", "attribute_value_mlt": [{"subitem_subject": "医学", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujisawa, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "102399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Otsuka, Fujio"}], "nameIdentifiers": [{"nameIdentifier": "102400", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-05-09"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "MR_22-5.pdf", "filesize": [{"value": "83.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 83700.0, "url": {"label": "MR_22-5.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/29429/files/MR_22-5.pdf"}, "version_id": "082cf9b1-1da2-4273-9f5e-ff7081dfcf75"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (\u003e4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (\u003e4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients"}]}, "item_type_id": "5", "owner": "1", "path": ["1789", "2562"], "permalink_uri": "http://hdl.handle.net/2241/120038", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-11-13"}, "publish_date": "2013-11-13", "publish_status": "0", "recid": "29429", "relation": {}, "relation_version_is_last": true, "title": ["The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (\u003e4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients"], "weko_shared_id": 5}
The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (>4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients
http://hdl.handle.net/2241/120038
http://hdl.handle.net/2241/12003878fdaf96-ffa5-4b4a-84fd-62432dd5e6af
名前 / ファイル | ライセンス | アクション |
---|---|---|
MR_22-5.pdf (83.7 kB)
|
|
Item type | Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-11-13 | |||||
タイトル | ||||||
タイトル | The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (>4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Fujisawa, Yasuhiro
× Fujisawa, Yasuhiro× Otsuka, Fujio |
|||||
著者別名 |
藤澤, 康弘
× 藤澤, 康弘 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The benefit of a sentinel lymph node (SLN) biopsy and adjuvant therapy for patients with thick (>4 mm) melanoma has not been well studied in the Asian population. We examined the benefit of an SLN biopsy and adjuvant therapy on prognosis in Japanese patients with thick melanoma. A review of the melanoma database collected from 26 institutions in Japan identified 291 patients with thick melanoma between 2005 and 2010. Univariate and multivariate analyses were performed to evaluate the factors predictive of the overall survival (OS) and the disease-free survival (DFS). Of the 242 patients with thick melanoma who underwent an SLN biopsy, the results for 96 (40%) were positive. On multivariate analysis, increased Breslow thickness (relative risk, 1.11; 95% confidence interval, 1.05–1.17; P=0.0002) and SLN metastasis (2.14; 1.04–4.43; P=0.040) were associated with a poor OS. Increased Breslow thickness (1.11; 1.04–1.18; P =0.0018), ulceration (3.11; 1.25–7.72; P=0.014), satellitosis (3.89; 1.62–9.31; P=0.0023), and SLN metastasis (2.24; 1.16–4.36; P=0.017) were associated with DFS. Adjuvant chemotherapy had no impact on either OS or DFS. Adjuvant use of a monthly dermal injection of interferon-β (IFN-β) was associated with a improvement in both OS (0.34; 0.17–0.67; P=0.0022) and DFS (0.42; 0.20–0.86; P=0.018). An SLN biopsy provided useful prognostic information and the adjuvant use of IFN-β improved both OS and DFS in Japanese patients with thick melanoma. These results were consistent with those of previous studies carried out on a white population. Therefore, we suggest that an SLN biopsy and adjuvantIFN should be considered for patients with thick melanoma irrespective of the Breslow thickness or ethnicity. | |||||
書誌情報 |
Melanoma research 巻 22, 号 5, p. 362-367, 発行日 2012-10 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1473-5636 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12569793 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22713797 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/CMR.0b013e328355e558 | |||||
権利 | ||||||
権利情報 | © 2012 Lippincott Williams & Wilkins, Inc. This is a non-final version of an article published in final form in Melanoma Research, Vol 22, Issue 5, Oct. 2012. |
|||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Lippincott Williams & Wilkins, Inc. | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/120038 | |||||
識別子タイプ | HDL |