{"created":"2021-03-01T07:07:38.669699+00:00","id":29180,"links":{},"metadata":{"_buckets":{"deposit":"ee1a52ee-0931-4e56-af53-f956531de963"},"_deposit":{"id":"29180","owners":[],"pid":{"revision_id":0,"type":"depid","value":"29180"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00029180","sets":["2780:1276","2780:1792","2780:556","2871:2876:1278","2871:2876:1994","2871:2876:927","3:62:5296:1807"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1688","bibliographicPageStart":"1685","bibliographicVolumeNumber":"95","bibliographic_titles":[{"bibliographic_title":"The annals of thoracic surgery"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"徳永, 千穂"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平松, 祐司"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"金本, 真也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋, 実穂"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"堀米, 仁志"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"榊原, 謙"}],"nameIdentifiers":[{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\n\nWhile β-blockers can be effective in controlling tachyarrhythmias after pediatric cardiac surgery, a negative inotropic influence sometimes complicates their use. Landiolol hydrochloride is a novel, ultra-short-acting β-blocker recently developed in Japan. The drug has higher β1:β2 selectivity ratio and a less negative inotropic effect. This study retrospectively evaluates the efficacy and safety of landiolol in the management of tachyarrhythmias after pediatric cardiac surgery.\nMethods\n\nA retrospective analysis was performed on 312 consecutive patients undergoing surgery for congenital heart disease. Twelve patients were treated with landiolol for critical tachyarrhythmia. The mean age of patients was 28.7 ± 10.6 months. Five junctional ectopic tachycardia, 2 atrial flutters, 1 paroxysmal supraventricular tachycardia, 1 atrial fibrillation, 1 atrioventricular reciprocating tachycardia with Wolff-Parkinson-White syndrome and 2 excessive sinus tachycardia were treated.\nResults\n\nThe mean loading and maintenance doses were 11.3 ± 4.0 and 6.8 ± 0.9 μg/kg per minute, respectively. Rate control was achieved in all patients. Landiolol reduced the heart rate from 169.7 ± 11.4 to 127.7 ± 7.5 beats per minute (p < 0.05) while blood pressure did not significantly change. Tachyarrhythmias were converted to sinus rhythm in 70.0% of the cases and the average time needed to achieve heart rate reduction was 2.3 ± 0.5 hours.\nConclusions\n\nLandiolol was efficacious in treating tachyarrhythmia in pediatric cardiac surgery. The desired negative chronotropic effect was achieved without significant hemodynamic compromise. The ultra-short half-life of landiolol provided rapid dose manipulation. This study suggests that landiolol is a promising option for the management of postoperative tachyarrhythmias in pediatric patients.","subitem_description_type":"Abstract"}]},"item_5_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/119455"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23506630","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.athoracsur.2013.01.057","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 The Society of Thoracic Surgeons  Published by Elsevier Inc. NOTICE: this is the author’s version of a work that was accepted for publication in The Annals of Thoracic Surgery. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Annals of Thoracic Surgery, [VOL95, ISSUE5, May 2013. DOI:10.1016/j.athoracsur.2013.01.057"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0003-4975","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11523822","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tokunaga, Chiho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiramatsu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanemoto, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi-Igari, Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Masakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horigome, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakakibara, Yuzuru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-25"}],"displaytype":"detail","filename":"ATS_95-5.pdf","filesize":[{"value":"278.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ATS_95-5.pdf","url":"https://tsukuba.repo.nii.ac.jp/record/29180/files/ATS_95-5.pdf"},"version_id":"cd815091-9ca1-49e9-8dc9-8d59b3410197"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Landiolol Hydrochloride on Intractable Tachyarrhythmia After Pediatric Cardiac Surgery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Landiolol Hydrochloride on Intractable Tachyarrhythmia After Pediatric Cardiac Surgery"}]},"item_type_id":"5","owner":"1","path":["1792","1276","556","1994","927","1278","1807"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-02"},"publish_date":"2013-07-02","publish_status":"0","recid":"29180","relation_version_is_last":true,"title":["Effects of Landiolol Hydrochloride on Intractable Tachyarrhythmia After Pediatric Cardiac Surgery"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T08:57:34.039907+00:00"}