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Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner
http://hdl.handle.net/2241/118016
http://hdl.handle.net/2241/11801641751fee-c0cd-4170-938a-58f6adb90305
名前 / ファイル | ライセンス | アクション |
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CC_10-21_suppl data.pdf (1.5 MB)
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CC_10-21_Article.pdf (3.1 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-12-05 | |||||
タイトル | ||||||
タイトル | Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Destici, Eugin
× Destici, Eugin× Oklejewicz, Małgorzata× Saito, Shoko× van, der Horst Gijsbertus T.J. |
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著者別名 |
齋藤, 祥子
× 齋藤, 祥子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | By gating cell cycle progression to specific times of the day, the intracellular circadian clock is thought to reduce the exposure of replicating cells to potentially hazardous environmental and endogenous genotoxic compounds. Although core clock gene defects that eradicate circadian rhythmicity can cause an altered in vivo genotoxic stress response and aberrant proliferation rate, it remains to be determined to what extent these cell cycle related phenotypes are due to a cell-autonomous lack of circadian oscillations. We investigated the DNA damage sensitivity and proliferative capacity of cultured primary Cry1‑/- | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cry2‑/- fibroblasts. Contrasting previous in vivo studies, we show that the absence of CRY proteins does not affect the cell-autonomous DNA damage response upon exposure of primary cells in vitro to genotoxic agents, but causes cells to proliferate faster. By comparing primary wild-type, Cry1‑/- | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cry2‑/-, Cry1+/- | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cry2-/- and Cry1-/- | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cry2+/- fibroblasts, we provide evidence that CRY proteins influence cell cycle progression in a cell-autonomous, but circadian clock-independent manner and that the accelerated cell cycle progression of Cry-deficient cells is caused by global dysregulation of Bmal1-dependent gene expression. These results suggest that the inconsistency between in vivo and in vitro observations might be attributed to systemic circadian control rather than a direct cell-autonomous control. | |||||
書誌情報 |
Cell cycle 巻 10, 号 21, p. 3788-3797, 発行日 2011-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1538-4101 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11638609 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22033214 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.4161/cc.10.21.17974 | |||||
権利 | ||||||
権利情報 | © 2011 Landes Bioscience | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Landes Bioscience | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/118016 | |||||
識別子タイプ | HDL |