@article{oai:tsukuba.repo.nii.ac.jp:00027890, author = {早川, 一郎 and 臼井, 健郎 and 木越, 英夫 and Hayakawa, Ichiro and Ikedo, Akiyuki and Chinen, Takumi and Usui, Takeo and 木越, 英夫}, issue = {19}, journal = {Bioorganic & medicinal chemistry}, month = {Oct}, note = {Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.}, pages = {5745--5756}, title = {Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone}, volume = {20}, year = {2012}, yomi = {キゴシ, ヒデオ} }