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  1. 生命環境系 (Faculty of Life and Environmental Sciences)
  2. 臼井 健郎 (Usui Takeo)
  1. 研究科 (Graduate School)
  2. 数理物質科学研究科 (Graduate School of Pure and Applied Sciences)
  3. 早川 一郎 (Hayakawa Ichiro)
  1. 筑波大学 (University of Tsukuba)
  2. 木越 英夫 (Kigoshi Hideo)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. B~
  4. Bioorganic & medicinal chemistry

Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone

http://hdl.handle.net/2241/117846
919ffe76-08a5-4e09-bf23-621ba014cadc
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BMC_20-19.pdf BMC_20-19.pdf (593.0 kB)
item type Journal Article(1)
公開日 2012-11-12
タイトル
タイトル Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
言語
言語 eng
資源タイプ
タイプ journal article
著者 Hayakawa, Ichiro

× Hayakawa, Ichiro

WEKO 96571

Hayakawa, Ichiro

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Ikedo, Akiyuki

× Ikedo, Akiyuki

WEKO 96572

Ikedo, Akiyuki

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Chinen, Takumi

× Chinen, Takumi

WEKO 96573

Chinen, Takumi

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Usui, Takeo

× Usui, Takeo

WEKO 96574

Usui, Takeo

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木越, 英夫

× 木越, 英夫

WEKO 88
e-Rad 90169839
筑波大学研究者総覧 0000000631

木越, 英夫

ja-Kana キゴシ, ヒデオ

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著者別名 早川, 一郎

× 早川, 一郎

WEKO 96576

早川, 一郎

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臼井, 健郎

× 臼井, 健郎

WEKO 461
e-Rad 60281648
筑波大学研究者総覧 0000001366

臼井, 健郎

Search repository
木越, 英夫

× 木越, 英夫

WEKO 88
e-Rad 90169839
筑波大学研究者総覧 0000000631

木越, 英夫

Search repository
抄録
内容記述 Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.
書誌情報 Bioorganic & medicinal chemistry

巻 20, 号 19, p. 5745-5756, 発行日 2012-10
ISSN
収録物識別子 0968-0896
書誌レコードID
収録物識別子 AA10938083
PubMed番号
関連識別子
関連識別子 22921744
DOI
関連識別子
関連識別子 10.1016/j.bmc.2012.08.005
権利
権利情報 © 2012 Elsevier Ltd.
NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic & medicinal chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, 20(19),2012 DOI:10.1016/j.bmc.2012.08.005
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出版者
出版者 Elsevier
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