@article{oai:tsukuba.repo.nii.ac.jp:00027571,
 author = {白木, 賢太郎 and Takai, Eisuke and Hirano, Atsushi and Shiraki, Kentaro},
 issue = {2},
 journal = {The journal of biochemistry},
 month = {Aug},
 note = {Alkyl gallates are anticipated for their use as antibacterial and antiviral agents. Although their pharmacological activities depend on their alkyl chain length, no mechanism has yet been clarified. As described herein, we investigated the membrane binding properties of a series of alkyl gallates using fluorescence measurement to elucidate their different pharmacological activities. Membrane binding of the alkyl gallates increased concomitantly with increasing alkyl chain length, except for cetyl gallate and stearyl gallate. Dynamic light scattering revealed that alkyl gallates with a long alkyl chain are prone to self-association in the solution. Membrane binding abilities of the alkyl gallates are correlated with antibacterial and antivirus activities, as described in previous reports. The partition constants of the alkyl gallates to lipid membranes depend on the membrane components and the membrane phase. Self-association and lipid binding of the alkyl gallates might be primary biophysical factors associated with their pharmacological activities.},
 pages = {165--171},
 title = {Effects of alkyl chain length of gallate on self-association and membrane-binding},
 volume = {150},
 year = {2011}
}