{"created":"2021-03-01T07:05:48.969142+00:00","id":27504,"links":{},"metadata":{"_buckets":{"deposit":"55de5c0e-9f21-44ec-b84b-805fda1a4677"},"_deposit":{"id":"27504","owners":[],"pid":{"revision_id":0,"type":"depid","value":"27504"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00027504","sets":["2778:1753","3:62:5592:1895"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageEnd":"3393","bibliographicPageStart":"3383","bibliographicVolumeNumber":"589","bibliographic_titles":[{"bibliographic_title":"The Journal of physiology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松井, 崇"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"征矢, 英昭"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"rain glycogen could be a critical energy source for brain activity when the glucose supply from the blood is inadequate (hypoglycemia). Although untested, it is hypothesized that during prolonged exhaustive exercise that induces hypoglycemia and muscular glycogen depletion, the resultant hypoglycemia may cause a decrease in brain glycogen. Here, we tested this hypothesis and also investigated the possible involvement of brain monoamines with the reduced levels of brain glycogen. For this purpose, we exercised male Wistar rats by treadmill for different durations (30-120 min) at moderate intensity (20 m/min) and measured brain glycogen levels of rats using the method of high-power microwave irradiation (10 kW). At the end of 30 and 60 min of running, the brain glycogen levels remained unchanged from resting levels, but liver and muscle glycogen decreased. After 120 min of running, the glycogen levels decreased significantly by 37~60% in five discrete brain loci (the cerebellum 60%, cortex 48%, hippocampus 43%, medulla oblongata 37%, and hypothalamus 34%) compared to those of the sedentary control. The brain glycogen levels in all five regions after running were positively correlated with the respective blood and brain glucose levels. Further, in the cortex, the levels of methoxyhydroxyphenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) with potential involvement in degradation of the brain glycogen increased during prolonged exercise and negatively correlated with the glycogen levels. These results support the hypothesis that brain glycogen could decrease with prolonged exhaustive exercise. Increased monoamines together with hypoglycemia should be associated with the development of decreased brain glycogen, suggesting new clue towards the understanding of central fatigue during prolonged exercise.","subitem_description_type":"Abstract"}]},"item_5_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/117388"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"the Physiological Society"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"21521757","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1113/jphysiol.2010.203570","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011, The Physiological Society"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-3751","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00253169","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsui, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soya, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichitani, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawanaka, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soya, Hideaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-25"}],"displaytype":"detail","filename":"JP_589-13.pdf","filesize":[{"value":"633.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JP_589-13.pdf","url":"https://tsukuba.repo.nii.ac.jp/record/27504/files/JP_589-13.pdf"},"version_id":"b672e972-9580-4dab-afe0-4fe433e13fdb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Brain glycogen decreases during prolonged exercise","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Brain glycogen decreases during prolonged exercise"}]},"item_type_id":"5","owner":"1","path":["1753","1895"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-12"},"publish_date":"2012-07-12","publish_status":"0","recid":"27504","relation_version_is_last":true,"title":["Brain glycogen decreases during prolonged exercise"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T08:55:23.913211+00:00"}