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  1. 医学医療系 (Faculty of Medicine)
  2. 鶴嶋 英夫 (Tsurushima Hideo)
  1. 医学医療系 (Faculty of Medicine)
  2. 大根田 修 (Ohneda Osamu)
  1. 医学医療系 (Faculty of Medicine)
  2. 山下 年晴 (Yamashita Toshiharu)
  1. 医学医療系 (Faculty of Medicine)
  2. 長野 真澄 (Nagano Masumi)
  1. 医学医療系 (Faculty of Medicine)
  2. 松村 明 (Matsumura Akira)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. B~
  4. Biochemical and biophysical research communications

A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats

http://hdl.handle.net/2241/116734
1de0d537-a81b-4d46-bd45-1948128eef5d
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名前 / ファイル ライセンス Actions
BBRC_418-1.pdf BBRC_418-1.pdf (823.4 kB)
item type Journal Article(1)
公開日 2012-03-30
タイトル
タイトル A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats
言語
言語 eng
資源タイプ
タイプ journal article
著者 Nakamura, Kazuhiro

× Nakamura, Kazuhiro

WEKO 92903

Nakamura, Kazuhiro

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Tsurushima, Hideo

× Tsurushima, Hideo

WEKO 92904

Tsurushima, Hideo

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Marushima, Aiki

× Marushima, Aiki

WEKO 92905

Marushima, Aiki

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Nagano, Masumi

× Nagano, Masumi

WEKO 92906

Nagano, Masumi

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Yamashita, Toshiharu

× Yamashita, Toshiharu

WEKO 92907

Yamashita, Toshiharu

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Suzuki, Kensuke

× Suzuki, Kensuke

WEKO 92908

Suzuki, Kensuke

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Ohneda, Osamu

× Ohneda, Osamu

WEKO 92909

Ohneda, Osamu

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Matsumura, Akira

× Matsumura, Akira

WEKO 92910

Matsumura, Akira

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著者別名 鶴嶋, 英夫

× 鶴嶋, 英夫

WEKO 455
e-Rad 50315470
筑波大学研究者総覧 0000001826

鶴嶋, 英夫

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長野, 真澄

× 長野, 真澄

WEKO 92912

長野, 真澄

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山下, 年晴

× 山下, 年晴

WEKO 204984
e-Rad 50400677
筑波大学研究者総覧 0000001879

山下, 年晴

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大根田, 修

× 大根田, 修

WEKO 161322
e-Rad 30311872
筑波大学研究者総覧 0000001616

大根田, 修

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松村, 明

× 松村, 明

WEKO 645
e-Rad 90241819
筑波大学研究者総覧 0000001792

松村, 明

Search repository
抄録
内容記述 Previous studies have examined the therapeutic effect of endothelial progenitor cells (EPCs) during the chronic phase of cerebral infarction in rats; however, few studies have investigated the effects of EPCs during the acute phase of infarction. In this study, we evaluated the therapeutic effect of EPCs with low aldehyde dehydrogenase activity (Alde-Low EPCs) in rats with acute cerebral infarction, and our results provide insight that may help to identify a therapeutic mechanism of EPCs for acute cerebral infarction. The administration of Alde-Low EPCs into rats with acute cerebral infarction results in the accumulation and migration of the Alde-Low EPCs into the infarct area and the subsequent decrease of infarct volume. Moreover, we found that the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) signaling pathway may regulate the accumulation of Alde-Low EPCs. The transplantation of Alde-Low EPCs may represent a potential treatment strategy for acute cerebral infarction.
書誌情報 Biochemical and biophysical research communications

巻 418, 号 1, p. 87-92, 発行日 2012-02
ISSN
収録物識別子 0006-291X
書誌レコードID
収録物識別子 AA00564395
PubMed番号
関連識別子
関連識別子 22244888
DOI
関連識別子
関連識別子 10.1016/j.bbrc.2011.12.139
権利
権利情報 © 2012 Elsevier Inc. NOTICE: this is the author's version of a work that was accepted for publication in BBRC. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, Volume 418(1), 2012, p87–92 DOI:10.1016/j.bbrc.2011.12.139
著者版フラグ
値 author
出版者
出版者 Elsevier Inc.
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