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A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats
http://hdl.handle.net/2241/116734
1de0d537-a81b-4d46-bd45-1948128eef5d
名前 / ファイル | ライセンス | Actions | |
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item type | Journal Article(1) | |||||
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公開日 | 2012-03-30 | |||||
タイトル | ||||||
タイトル | A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
タイプ | journal article | |||||
著者 |
Nakamura, Kazuhiro
× Nakamura, Kazuhiro× Tsurushima, Hideo× Marushima, Aiki× Nagano, Masumi× Yamashita, Toshiharu× Suzuki, Kensuke× Ohneda, Osamu× Matsumura, Akira |
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著者別名 |
鶴嶋, 英夫
× 鶴嶋, 英夫× 長野, 真澄× 山下, 年晴× 大根田, 修× 松村, 明 |
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抄録 | ||||||
内容記述 | Previous studies have examined the therapeutic effect of endothelial progenitor cells (EPCs) during the chronic phase of cerebral infarction in rats; however, few studies have investigated the effects of EPCs during the acute phase of infarction. In this study, we evaluated the therapeutic effect of EPCs with low aldehyde dehydrogenase activity (Alde-Low EPCs) in rats with acute cerebral infarction, and our results provide insight that may help to identify a therapeutic mechanism of EPCs for acute cerebral infarction. The administration of Alde-Low EPCs into rats with acute cerebral infarction results in the accumulation and migration of the Alde-Low EPCs into the infarct area and the subsequent decrease of infarct volume. Moreover, we found that the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) signaling pathway may regulate the accumulation of Alde-Low EPCs. The transplantation of Alde-Low EPCs may represent a potential treatment strategy for acute cerebral infarction. | |||||
書誌情報 |
Biochemical and biophysical research communications 巻 418, 号 1, p. 87-92, 発行日 2012-02 |
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ISSN | ||||||
収録物識別子 | 0006-291X | |||||
書誌レコードID | ||||||
収録物識別子 | AA00564395 | |||||
PubMed番号 | ||||||
関連識別子 | ||||||
関連識別子 | 22244888 | |||||
DOI | ||||||
関連識別子 | ||||||
関連識別子 | 10.1016/j.bbrc.2011.12.139 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Inc. NOTICE: this is the author's version of a work that was accepted for publication in BBRC. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, Volume 418(1), 2012, p87–92 DOI:10.1016/j.bbrc.2011.12.139 | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier Inc. |