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In this study, we evaluated the therapeutic effect of EPCs with low aldehyde dehydrogenase activity (Alde-Low EPCs) in rats with acute cerebral infarction, and our results provide insight that may help to identify a therapeutic mechanism of EPCs for acute cerebral infarction. The administration of Alde-Low EPCs into rats with acute cerebral infarction results in the accumulation and migration of the Alde-Low EPCs into the infarct area and the subsequent decrease of infarct volume. Moreover, we found that the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) signaling pathway may regulate the accumulation of Alde-Low EPCs. The transplantation of Alde-Low EPCs may represent a potential treatment strategy for acute cerebral infarction.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/116734"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "22244888", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.bbrc.2011.12.139", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2012 Elsevier Inc.\u3000NOTICE: this is the author\u0027s version of a work that was accepted for publication in BBRC. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, Volume 418(1), 2012, p87\u201392 DOI:10.1016/j.bbrc.2011.12.139"}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00564395", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakamura, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "92903", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsurushima, Hideo"}], "nameIdentifiers": [{"nameIdentifier": "92904", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Marushima, Aiki"}], "nameIdentifiers": [{"nameIdentifier": "92905", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagano, Masumi"}], "nameIdentifiers": [{"nameIdentifier": "92906", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamashita, Toshiharu"}], "nameIdentifiers": [{"nameIdentifier": "92907", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Kensuke"}], "nameIdentifiers": [{"nameIdentifier": "92908", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohneda, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "92909", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumura, Akira"}], "nameIdentifiers": [{"nameIdentifier": "92910", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "BBRC_418-1.pdf", "filesize": [{"value": "823.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 823400.0, "url": {"label": "BBRC_418-1.pdf", "url": "https://tsukuba.repo.nii.ac.jp/record/26972/files/BBRC_418-1.pdf"}, "version_id": "ccaf18d7-a329-4ed0-8900-fcea4a76e16b"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats"}]}, "item_type_id": "5", "owner": "1", "path": ["2780/1974", "2780/1287", "2780/1996", "2780/1977", "2780/926", "3/62/5297/184"], "permalink_uri": "http://hdl.handle.net/2241/116734", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2012-03-30"}, "publish_date": "2012-03-30", "publish_status": "0", "recid": "26972", "relation": {}, "relation_version_is_last": true, "title": ["A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats"], "weko_shared_id": 5}