{"created":"2021-03-01T07:04:33.435208+00:00","id":26350,"links":{},"metadata":{"_buckets":{"deposit":"8e260bcc-84be-4354-ac90-17de2d4b4db5"},"_deposit":{"id":"26350","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26350"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00026350","sets":["2780:956","2871:2876:348","3:62:5296:1810"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"121","bibliographicPageStart":"113","bibliographicVolumeNumber":"132","bibliographic_titles":[{"bibliographic_title":"Archives of Orthopaedic and Trauma Surgery"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"六崎, 裕高"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂根, 正孝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"落合, 直之"}],"nameIdentifiers":[{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND:\n\nPin-tract infections are the most common complications of external fixation. To solve the problem, we developed a fibroblast growth factor-2 (FGF-2)-apatite composite layer for coating titanium screws. The purpose of this study was to elucidate the mechanism of the improvement in infection resistance associated with FGF-2-apatite composite layers.\nMETHOD:\n\nWe analyzed FGF-2 release from the FGF-2-apatite composite layer and the mitogenic activity of the FGF-2-apatite composite layer. We evaluated time-dependent development of macroscopic pin-tract infection around uncoated titanium control screws (n = 10). Screws coated with the apatite layer (n = 16) and FGF-2-apatite composite layer (n = 16) were percutaneously implanted for 4 weeks in the medial proximal tibia in rabbits.\nRESULTS:\n\nA FGF-2-apatite composite layer coated on the screws led to the retention of the mitogenic activity of FGF-2. FGF-2 was released from the FGF-2-apatite composite layer in vitro for at least 4 days, which corresponds to a period when 30% of pin-tract infections develop macroscopically in the percutaneous implantation of uncoated titanium control screws. The macroscopic infection rate increased with time, reaching a plateau of 80-90% within 12 days. This value remained unchanged until 4 weeks after implantation. The screws coated with an FGF-2-apatite composite layer showed a significantly higher wound healing rate than those coated with an apatite layer (31.25 vs. 6.25%, p < 0.05). The interfacial soft tissue that bonded to the FGF-2-apatite composite layer is a Sharpey's fiber-like tissue, where collagen fibers are inclined at angles from 30 to 40° to the screw surface. The Sharpey's Wber-like tissue is rich in blood vessels and directly bonds to the FGF-2-apatite composite layer via a thin cell monolayer (0.8-1.7 μm thick).\nCONCLUSION:\n\nIt is suggested that the enhanced wound healing associated with the formation of Sharpey's fiber-like tissue triggered by FGF-2 released from the FGF-2-apatite composite layer leads to the reduction in the pin-tract inflammation rate.","subitem_description_type":"Abstract"}]},"item_5_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/115329"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"21904932","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00402-011-1381-7","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer-Verlag 2011\nThe original publication is available at www.springerlink.com"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0936-8051","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10738765","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mutsuzaki, Hirotaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Atsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sogo, Yu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakane, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oyane, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ochiai, Naoyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-25"}],"displaytype":"detail","filename":"AOTS_132-1.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AOTS_132-1.pdf","url":"https://tsukuba.repo.nii.ac.jp/record/26350/files/AOTS_132-1.pdf"},"version_id":"9ca5bb89-8846-4a7b-b2c8-29c160d451a5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Enhanced wound healing associated with Sharpey’s fiber-like tissue formation around FGF-2-apatite composite layers on percutaneous titanium screws in rabbits","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhanced wound healing associated with Sharpey’s fiber-like tissue formation around FGF-2-apatite composite layers on percutaneous titanium screws in rabbits"}]},"item_type_id":"5","owner":"1","path":["956","348","1810"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-22"},"publish_date":"2012-02-22","publish_status":"0","recid":"26350","relation_version_is_last":true,"title":["Enhanced wound healing associated with Sharpey’s fiber-like tissue formation around FGF-2-apatite composite layers on percutaneous titanium screws in rabbits"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-04-27T08:54:06.681961+00:00"}