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Enhanced wound healing associated with Sharpey’s fiber-like tissue formation around FGF-2-apatite composite layers on percutaneous titanium screws in rabbits
http://hdl.handle.net/2241/115329
http://hdl.handle.net/2241/1153291013935e-29cc-44c1-bcb0-1d9f39a5ca59
名前 / ファイル | ライセンス | アクション |
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AOTS_132-1.pdf (1.3 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-02-22 | |||||
タイトル | ||||||
タイトル | Enhanced wound healing associated with Sharpey’s fiber-like tissue formation around FGF-2-apatite composite layers on percutaneous titanium screws in rabbits | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Mutsuzaki, Hirotaka
× Mutsuzaki, Hirotaka× Ito, Atsuo× Sogo, Yu× Sakane, Masataka× Oyane, Ayako× Ochiai, Naoyuki |
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著者別名 |
六崎, 裕高
× 六崎, 裕高× 坂根, 正孝× 落合, 直之 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Pin-tract infections are the most common complications of external fixation. To solve the problem, we developed a fibroblast growth factor-2 (FGF-2)-apatite composite layer for coating titanium screws. The purpose of this study was to elucidate the mechanism of the improvement in infection resistance associated with FGF-2-apatite composite layers. METHOD: We analyzed FGF-2 release from the FGF-2-apatite composite layer and the mitogenic activity of the FGF-2-apatite composite layer. We evaluated time-dependent development of macroscopic pin-tract infection around uncoated titanium control screws (n = 10). Screws coated with the apatite layer (n = 16) and FGF-2-apatite composite layer (n = 16) were percutaneously implanted for 4 weeks in the medial proximal tibia in rabbits. RESULTS: A FGF-2-apatite composite layer coated on the screws led to the retention of the mitogenic activity of FGF-2. FGF-2 was released from the FGF-2-apatite composite layer in vitro for at least 4 days, which corresponds to a period when 30% of pin-tract infections develop macroscopically in the percutaneous implantation of uncoated titanium control screws. The macroscopic infection rate increased with time, reaching a plateau of 80-90% within 12 days. This value remained unchanged until 4 weeks after implantation. The screws coated with an FGF-2-apatite composite layer showed a significantly higher wound healing rate than those coated with an apatite layer (31.25 vs. 6.25%, p < 0.05). The interfacial soft tissue that bonded to the FGF-2-apatite composite layer is a Sharpey's fiber-like tissue, where collagen fibers are inclined at angles from 30 to 40° to the screw surface. The Sharpey's Wber-like tissue is rich in blood vessels and directly bonds to the FGF-2-apatite composite layer via a thin cell monolayer (0.8-1.7 μm thick). CONCLUSION: It is suggested that the enhanced wound healing associated with the formation of Sharpey's fiber-like tissue triggered by FGF-2 released from the FGF-2-apatite composite layer leads to the reduction in the pin-tract inflammation rate. |
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書誌情報 |
Archives of Orthopaedic and Trauma Surgery 巻 132, 号 1, p. 113-121, 発行日 2011 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0936-8051 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10738765 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 21904932 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00402-011-1381-7 | |||||
権利 | ||||||
権利情報 | © Springer-Verlag 2011 The original publication is available at www.springerlink.com |
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著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Springer | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/115329 | |||||
識別子タイプ | HDL |