{"created":"2021-03-01T07:04:11.997895+00:00","id":26025,"links":{},"metadata":{"_buckets":{"deposit":"34feaf8d-493b-41e4-92a9-2224ba12b399"},"_deposit":{"id":"26025","owners":[],"pid":{"revision_id":0,"type":"depid","value":"26025"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00026025","sets":["2780:1494","3:62:5595:431"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"55","bibliographicPageStart":"48","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Molecular immunology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山内, 一由"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mutations and polymorphisms of factor H gene (FH1) are known to be closely involved in the development\nof atypical hemolytic uremic syndrome (aHUS). Several groups have identified disease risk mutations and\npolymorphisms of FH1 for the development of aHUS, and have investigated frequencies of aHUS in a number\nof ethnic groups. However, such studies on Japanese populations are limited. In the present study,\nwe analyzed FH1 in Japanese aHUS patients and healthy volunteers, and examined whether those variants\nimpacted on a tendency for the development of aHUS in Japanese populations. Similar to previous\nstudies, we found that a high frequency of FH1 mutations, located in exon 23 of FH1, encodes short consensus\nrepeat 20 in C-terminal end of factor H molecule in patients with aHUS (40%), but not in healthy\nvolunteers. Interestingly, no significant differences in frequency of well-known disease risk polymorphisms\nfor aHUS were observed between healthy volunteers and aHUS patients. Our results suggested\nthat although FH1 mutations relates to the development of Japanese aHUS in accordance with other ethnic\nstudies, other factor may be required for factor H polymorphism to be a risk factor of Japanese aHUS.","subitem_description_type":"Abstract"}]},"item_5_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/115013"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"21868097","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.molimm.2011.07.017","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 Elsevier Ltd.\nNOTICE: this is the author’s version of a work that was accepted for publication in Molecular Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, Volume 49(1-2),2011, P.48-55 DOI：10.1016/j.molimm.2011.07.017"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0161-5890","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00307483","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mukai, Saki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Yoshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirota-Kawadobora, Masako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujihara, Noriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takezawa, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubota, Seiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koike, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamauchi, Kazuyoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-25"}],"displaytype":"detail","filename":"MI_49-1.pdf","filesize":[{"value":"205.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MI_49-1.pdf","url":"https://tsukuba.repo.nii.ac.jp/record/26025/files/MI_49-1.pdf"},"version_id":"54cd1971-f2e7-4aca-b85c-144bd8a45aad"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Factor H gene variants in Japanese: Its relation to atypical hemolytic uremic syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Factor H gene variants in Japanese: Its relation to atypical hemolytic uremic syndrome"}]},"item_type_id":"5","owner":"1","path":["1494","431"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-03"},"publish_date":"2012-02-03","publish_status":"0","recid":"26025","relation_version_is_last":true,"title":["Factor H gene variants in Japanese: Its relation to atypical hemolytic uremic syndrome"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T08:53:47.742769+00:00"}