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  1. 医学医療系 (Faculty of Medicine)
  2. 杉山 文博 (Sugiyama Fumihiro)
  1. 医学医療系 (Faculty of Medicine)
  2. 八神 健一 (Yagami Ken-ichi)
  1. 研究科 (Graduate School)
  2. 人間総合科学研究科 (Graduate School of Comprehensive Human Sciences)
  3. 國田 智 (Kunita Satoshi)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. E~
  4. Experimental animals

Retrotransposon-Mediated Fgf5go-Utr Mutant Mice with Long Pelage Hair

http://hdl.handle.net/2241/113251
f0415e58-2604-422d-b24a-2708630ca0c6
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EA_60-2.pdf EA_60-2.pdf (571.7 kB)
item type Journal Article(1)
公開日 2011-06-10
タイトル
タイトル Retrotransposon-Mediated Fgf5go-Utr Mutant Mice with Long Pelage Hair
言語
言語 eng
資源タイプ
タイプ journal article
著者 MIZUNO, Seiya

× MIZUNO, Seiya

WEKO 85532

MIZUNO, Seiya

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IIJIMA, Saori

× IIJIMA, Saori

WEKO 85533

IIJIMA, Saori

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OKANO, Tomoko

× OKANO, Tomoko

WEKO 85534

OKANO, Tomoko

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KAJIWARA, Noriko

× KAJIWARA, Noriko

WEKO 85535

KAJIWARA, Noriko

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KUNITA, Satoshi

× KUNITA, Satoshi

WEKO 85536

KUNITA, Satoshi

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SUGIYAMA, Fumihiro

× SUGIYAMA, Fumihiro

WEKO 85537

SUGIYAMA, Fumihiro

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YAGAMI, Ken-ichi

× YAGAMI, Ken-ichi

WEKO 85538

YAGAMI, Ken-ichi

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著者別名 國田, 智

× 國田, 智

WEKO 85539

國田, 智

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杉山, 文博

× 杉山, 文博

WEKO 560
e-Rad 90226481
筑波大学研究者総覧 0000001632

杉山, 文博

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八神, 健一

× 八神, 健一

WEKO 85541

八神, 健一

Search repository
抄録
内容記述 We found 6 spontaneous mutant mice with long pelage hair in our ICR breeding colony. The abnormal trait was restricted to long hair in these mice, which we named moja. They were fertile and showed the same growth and behavior as wild-type mice. To investigate the manner of the genetic inheritance of the moja allele, offspring were bred by mating the moja mice; all offspring had long pelage hair. Furthermore, we performed a reciprocal cross between moja mice and wild-type ICR mice with normal hair. All offspring exhibited normal hair suggesting an autosomal recessive inheritance of the trait. The moja/moja hair phenotype was maintained in skin grafted onto nude mice, suggesting that circulating or diffusible humoral factors regulating the hair cycle are not involved in the abnormal trait. The phenotype of moja/moja mice is similar to that of Fgf5-deficient mice. Therefore, we examined the expression of Fgf5 by RT-PCR in moja/moja mice. As expected, no Fgf5 expression was found in moja/moja mouse skin. PCR and DNA sequence analyses were performed to investigate the structure of the Fgf5 gene. We found a deletion of a 9.3-kb region in the Fgf5 gene including exon 3 and its 5’ and 3’ flanking sequences. Interestingly, the genomic deletion site showed insertion of a 498-bp early transposon element long terminal repeat. Taken together, these results suggest that the long hair mutation of moja/moja mice is caused by disruption of Fgf5 mediated by insertion of a retrotransposon.
書誌情報 Experimental animals

巻 60, 号 2, p. 161-167, 発行日 2011-04
ISSN
収録物識別子 1341-1357
書誌レコードID
収録物識別子 AA11032321
PubMed番号
関連識別子
関連識別子 21512271
DOI
関連識別子
関連識別子 10.1538/expanim.60.161
権利
権利情報 (c) 2011 Japanese Association for Laboratory Animal Science
著者版フラグ
値 publisher
出版者
出版者 Japanese Association for Laboratory Animal Science
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